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Galeterone functions both as an inhibitor of CYP17A1 and anti-androgen, as it binds the androgen receptor, acting as an competitive antagonist and also preventing Ar protein binding to chromatin and enhancing degradation of mutant Ar protein (PMID: 24874833, PMID: 31653008).
|DrugClasses||Hormone - Anti-androgens 29|
|CAS Registry Number||851983-85-2|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|Galeterone + Gemcitabine||Galeterone Gemcitabine||0||1|