Drug Detail


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Drug Name Cyclopamine
Trade Name
Synonyms 11-Deoxyjervine
Drug Descriptions

Cyclopamine (11-Deoxyjervine) is a plant-derived alkaloid that inhibits the Hedgehog signaling pathway, resulting in growth inhibition in cells with activated SMO or inactivated PTCH (PMID: 10984056, PMID: 32622951).

DrugClasses SMO Inhibitor 16
CAS Registry Number 4449-51-8
NCIT ID C63945


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Therapy Name Drugs Efficacy Evidence Clinical Trials
Cyclopamine Cyclopamine 0 0
Cyclopamine + Posaconazole Cyclopamine Posaconazole 0 0

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