Drug Detail


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Drug Name GSK3174998
Trade Name
Synonyms GSK-3174998|GSK 3174998
Drug Descriptions

GSK3174998 is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response (Cancer Res July 15 2016 (76) (14 Supplement) CT027).

DrugClasses OX40 Antibody 12
CAS Registry Number 2089398-68-3
NCIT ID C124783


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Therapy Name Drugs Efficacy Evidence Clinical Trials
belantamab mafodotin-blmf + GSK3174998 GSK3174998 belantamab mafodotin-blmf 0 1
GSK1795091 + GSK3174998 GSK1795091 GSK3174998 0 1
GSK3174998 GSK3174998 0 2
GSK3174998 + Pembrolizumab GSK3174998 Pembrolizumab 0 0

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