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Drug Name | DS-1001b |
Trade Name | |
Synonyms | DS-1001|DS1001|Safusidenib|AB-218|AB218|AB 218 |
Drug Descriptions |
DS-1001b specifically targets IDH1 mutations, including at amino acid R132, which results in decreased 2HG production and potentially leads to increased differentiation and decreased proliferation of IDH1 mutant cancer cells (PMID: 31727689, PMID: 31406254). |
DrugClasses | IDH1 Inhibitor 8 |
CAS Registry Number | 1898207-64-1 |
NCIT ID | C148134 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
DS-1001b | DS-1001b | 6 | 2 |