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Drug Name DS-1001b
Trade Name
Synonyms DS-1001|DS1001|Safusidenib|AB-218|AB218|AB 218
Drug Descriptions

DS-1001b specifically targets IDH1 mutations, including at amino acid R132, which results in decreased 2HG production and potentially leads to increased differentiation and decreased proliferation of IDH1 mutant cancer cells (PMID: 31727689, PMID: 31406254).

DrugClasses IDH1 Inhibitor 8
CAS Registry Number 1898207-64-1
NCIT ID C148134

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Therapy Name Drugs Efficacy Evidence Clinical Trials
DS-1001b DS-1001b 6 2


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