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Drug Name SRF231
Trade Name
Synonyms SRF 231|SRF-231
Drug Descriptions

SRF231 is monoclonal antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells (Blood 2016 128:1843, PMID: 28286286) and may also stimulate cytotoxic T-cells (PMID: 29873856, PMID: 32345627).

DrugClasses CD47 Antibody 20 Immune Checkpoint Inhibitor 147
CAS Registry Number NA
NCIT ID C155976

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Therapy Name Drugs Efficacy Evidence Clinical Trials
SRF231 SRF231 0 1


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