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SRF231 is monoclonal antibody against CD47 that binds to and blocks CD47 downstream signaling and subsequent activation of the SIRPa receptor on macrophages, leading to phagocytosis of tumor cells (Blood 2016 128:1843, PMID: 28286286) and may also stimulate cytotoxic T-cells (PMID: 29873856, PMID: 32345627).
|DrugClasses||CD47 Antibody 20 Immune Checkpoint Inhibitor 147|
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|