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ORIN1001 is an inhibitor of IRE1, which binds to the RNase domain of Ire1, potentially leading to inhibition of the IRE1/XBP1 pathway and subsequent tumor growth, and may result in an immune response via repression of the immunosuppressive tumor microenvironment (NCI Drug Dictionary).
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|ORIN1001 + Paclitaxel||ORIN1001 Paclitaxel||0||1|