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Drug Name | ORIN1001 |
Trade Name | |
Synonyms | ORIN-1001|ORIN 1001 |
Drug Descriptions |
ORIN1001 is an inhibitor of IRE1, which binds to the RNase domain of Ire1, potentially leading to inhibition of the IRE1/XBP1 pathway and subsequent tumor growth, and may result in an immune response via repression of the immunosuppressive tumor microenvironment (NCI Drug Dictionary). |
DrugClasses | |
CAS Registry Number | NA |
NCIT ID | C176578 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
ORIN1001 | ORIN1001 | 0 | 1 |
ORIN1001 + Paclitaxel | ORIN1001 Paclitaxel | 0 | 1 |