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|Drug Name||EGFRt/19-28z/4-1BBL CAR T cells|
EGFRt/19-28z/4-1BBL CAR T cells are autologous T-cells engineered to express TNFSF9 (4-1BBL) and a chimeric antigen receptor (CAR) targeting CD19 linked to CD28 and CD3zeta signaling domains as well as a truncated EGFR, which may relieve immunosuppression and enhance cytotoxicity against CD19-expressing tumor cells (NCI Thesaurus).
|CAS Registry Number||NA|
|Therapy Name||Drugs||Efficacy Evidence||Clinical Trials|
|EGFRt/19-28z/4-1BBL CAR T cells||EGFRt/19-28z/4-1BBL CAR T cells||0||1|