Drug Detail


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Drug Name 225Ac-J591
Trade Name
Synonyms Ac 225 MOAB J591|Ac-225 Anti-PSMA J591
Drug Descriptions

225Ac-J591 is a radioconjugate comprising the alpha-radiation emitting radionuclide actinium-225 linked to a monoclonal antibody that targets PSMA (J591), which delivers radiation to PSMA-expressing tumor cells, potentially resulting in antitumor activity (Cancer Res 2017;77(13 Suppl):Abstract nr 5201).

DrugClasses PSMA Antibody 12
CAS Registry Number NA
NCIT ID C153159


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Therapy Name Drugs Efficacy Evidence Clinical Trials
225Ac-J591 225Ac-J591 0 3
225Ac-J591 + Pembrolizumab 225Ac-J591 Pembrolizumab 0 1
225Ac-J591 + PNT2002 225Ac-J591 PNT2002 0 1

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