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Gene Symbol CTNNB1
Synonyms armadillo | CTNNB | EVR7 | MRD19 | NEDSDV
Gene Description CTNNB1, catenin beta 1, is a member of the Wnt signaling pathway, component of cadherin-based adherens junctions, and is also a tumor antigen recognized by T-cells in melanoma (PMID: 29403496). CTNNB1 imbalance is implicated in cancer progression and metastasis (PMID: 22617422) and exon 3 mutations are common in endometrioid endometrial carcinoma and melanoma (PMID: 29435196).

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Molecular Profile Protein Effect Treatment Approaches
CTNNB1 A13T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A20V unknown
CTNNB1 A21T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A21_A149del unknown
CTNNB1 A21_A152del unknown
CTNNB1 A39G gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A39T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A43P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A43T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 A43V unknown
CTNNB1 A5_A80del unknown
CTNNB1 A5_Q143del unknown
CTNNB1 A702V unknown
CTNNB1 A97fs loss of function - predicted
CTNNB1 act mut gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 amp no effect
CTNNB1 - PLAG1 unknown
CTNNB1 D11V unknown
CTNNB1 D162E unknown
CTNNB1 D32A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32E gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32G gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32H gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32N gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32V gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D32Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 D712N unknown
CTNNB1 dec exp no effect
CTNNB1 E15K unknown
CTNNB1 E396D unknown
CTNNB1 E462K unknown
CTNNB1 E54K gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 E55K unknown
CTNNB1 E571* loss of function - predicted
CTNNB1 E67K gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34* loss of function - predicted
CTNNB1 G34A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34E gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34R gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G34V gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G367R unknown
CTNNB1 G38A unknown
CTNNB1 G38C unknown
CTNNB1 G38D unknown
CTNNB1 G38fs loss of function - predicted
CTNNB1 G38P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G38V unknown
CTNNB1 G48D gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 G50D unknown
CTNNB1 G69A unknown
CTNNB1 H24P unknown
CTNNB1 H24_H36del unknown
CTNNB1 H24_Y142del unknown
CTNNB1 H36P gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 H36R unknown
CTNNB1 H36Y gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 I140N unknown
CTNNB1 I35del unknown
CTNNB1 I35N gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 I35S gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 I35T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 I35V unknown
CTNNB1 I35_G38del unknown
CTNNB1 inact mut loss of function
CTNNB1 K335I gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 K335T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 K354Q unknown
CTNNB1 K354T unknown
CTNNB1 K49E unknown
CTNNB1 L10_N141del unknown
CTNNB1 L31M unknown
CTNNB1 L31_I35del unknown
CTNNB1 L405F unknown
CTNNB1 L487fs loss of function - predicted
CTNNB1 L762* loss of function - predicted
CTNNB1 M12_D144del unknown
CTNNB1 M553V unknown
CTNNB1 M8_L132del unknown
CTNNB1 mutant unknown
CTNNB1 mut NRAS mut
CTNNB1 mut PIK3CA mut
CTNNB1 N287S unknown
CTNNB1 N387K gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 N415H unknown
CTNNB1 N772* loss of function - predicted
CTNNB1 over exp no effect
CTNNB1 over exp PIK3CA wild-type
CTNNB1 P16S unknown
CTNNB1 P16_K133del unknown
CTNNB1 P44A gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 P44H unknown
CTNNB1 P44L unknown
CTNNB1 P44S unknown
CTNNB1 P44_S45del gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 P52H unknown
CTNNB1 Q193* loss of function - predicted
CTNNB1 Q302H unknown
CTNNB1 Q322K unknown
CTNNB1 Q703H unknown
CTNNB1 R151fs loss of function - predicted
CTNNB1 R18_R151delinsS unknown
CTNNB1 R376H gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 R453L unknown
CTNNB1 R453Q unknown
CTNNB1 R515Q unknown
CTNNB1 R535* loss of function - predicted
CTNNB1 R535Q unknown
CTNNB1 R542H unknown
CTNNB1 R582P unknown
CTNNB1 R582W no effect - predicted
CTNNB1 R587Q unknown
CTNNB1 R717C unknown
CTNNB1 R95* loss of function - predicted
CTNNB1 S23G no effect - predicted
CTNNB1 S23R unknown
CTNNB1 S23_S33del unknown
CTNNB1 S29F no effect - predicted
CTNNB1 S29Y unknown
CTNNB1 S33A gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33C gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33F gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33L gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33N gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S33Y PIK3CA mut
CTNNB1 S37A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37C gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37F gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37P gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S37Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45C gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45del gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45F gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45fs loss of function - predicted
CTNNB1 S45N gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45P gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45T gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45Y gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 S45_L46insTSS unknown
CTNNB1 S45_V57del unknown
CTNNB1 S47L unknown
CTNNB1 S73P unknown
CTNNB1 T257I unknown
CTNNB1 T3_A126del unknown
CTNNB1 T40I unknown
CTNNB1 T40S unknown
CTNNB1 T41A gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 T41I gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 T41N unknown
CTNNB1 T41P unknown
CTNNB1 T41S unknown
CTNNB1 T41_P52del unknown
CTNNB1 T42fs loss of function - predicted
CTNNB1 T42I unknown
CTNNB1 T42K unknown
CTNNB1 T42R unknown
CTNNB1 T42_A43insSS unknown
CTNNB1 V199I unknown
CTNNB1 V22A gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 V22G unknown
CTNNB1 V22I unknown
CTNNB1 V22_A97del unknown
CTNNB1 V22_D145del unknown
CTNNB1 V22_G38del unknown
CTNNB1 V22_S33del unknown
CTNNB1 V22_Y64del unknown
CTNNB1 W25* loss of function - predicted
CTNNB1 W25L unknown
CTNNB1 W25_D32del gain of function - predicted CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 W25_H36del gain of function - predicted
CTNNB1 W383G gain of function - predicted
CTNNB1 W383K unknown
CTNNB1 W383R gain of function CTNNB1 Inhibitor PDPK1 Inhibitor Tankyrase Inhibitor
CTNNB1 W66* loss of function - predicted
CTNNB1 wild-type no effect
APC wild-type CTNNB1 wild-type
CTNNB1 wild-type PIK3CA mut
CTNNB1 Y30* loss of function - predicted
CTNNB1 Y30fs loss of function - predicted
CTNNB1 Y30_S33del unknown
CTNNB1 Y670* loss of function - predicted