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Gene RET
Variant A883F
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET A883F lies within the protein kinase domain of the Ret protein (UniProt.org). A883F confers a gain of function to the Ret protein as demonstrated by increased Ret kinase activity (PMID: 24561444) and is transforming in cell culture (PMID: 10445857, PMID: 10679286).
Associated Drug Resistance
Category Variants Paths

RET mutant RET A883X RET A883F

RET mutant RET act mut RET A883F

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Transcript NM_020975.6
gDNA chr10:g.43120120_43120121delGCinsTT
cDNA c.2647_2648delGCinsTT
Protein p.A883F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975.5 chr10:g.43120120_43120121delGCinsTT c.2647_2648delGCinsTT p.A883F RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120120_43120121delGCinsTT c.2647_2648delGCinsTT p.A883F RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43120120_43120121delGCinsTT c.2647_2648delGCinsTT p.A883F RefSeq GRCh38/hg38
NM_020630 chr10:g.43120120_43120121delGCinsTT c.2647_2648delGCinsTT p.A883F RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120120_43120121delGCinsTT c.2647_2648delGCinsTT p.A883F RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120120_43120121delGCinsTT c.2647_2648delGCinsTT p.A883F RefSeq GRCh38/hg38
NM_020975 chr10:g.43120120_43120121delGCinsTT c.2647_2648delGCinsTT p.A883F RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120120_43120121delGCinsTT c.2647_2648delGCinsTT p.A883F RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120120_43120121delGCinsTT c.2647_2648delGCinsTT p.A883F RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120120_43120121delGCinsTT c.2647_2648delGCinsTT p.A883F RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET A883F Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited phosphorylation of Ret in transformed human cells expressing RET A883F in culture (PMID: 23526464). 23526464
RET A883F Advanced Solid Tumor sensitive Vandetanib Preclinical Actionable In a preclinical study, Caprelsa (vandetanib) inhibited Ret autophosphorylation in transformed cells expressing RET A883F in culture (PMID: 15184865). 15184865