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Gene RET
Variant D898V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions RET D898V lies within the protein kinase domain of the Ret protein (UniProt.org). D898V has been identified in the scientific literature (PMID: 23526464), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

RET mutant RET D898V

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Transcript NM_020975.6
gDNA chr10:g.43120166A>T
cDNA c.2693A>T
Protein p.D898V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43120166A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43120166A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_001406769.1 chr10:g.43126624A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_020630 chr10:g.43120166A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43120166A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43120166A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43120166A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_020975 chr10:g.43120166A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43120166A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43120166A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_001406772.1 chr10:g.43126624A>T c.2693A>T p.D898V RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43120166A>T c.2693A>T p.D898V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET D898V Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited phosphorylation of Ret in transformed human cells expressing RET D898V in culture (PMID: 23526464). 23526464