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Gene CHEK1
Variant G289*
Impact List nonsense
Protein Effect unknown
Gene Variant Descriptions CHEK1 G289* results in a premature truncation of the Chek1 protein at amino acid 289 of 476 (UniProt.org). G289* has not been characterized in the scientific literature and therefore, its effect on Chek1 protein function is unknown (PubMed, Oct 2023).
Associated Drug Resistance
Category Variants Paths

CHEK1 mutant CHEK1 G289*

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Transcript NM_001114121.2
gDNA chr11:g.125643842G>T
cDNA c.865G>T
Protein p.G289*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001114121 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
XM_017017146 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001114122 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
XM_017017146.2 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
XM_047426311.1 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001114121.2 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
XM_024448337.2 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001114121.2 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
XM_024448337.1 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001244846 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001244846.1 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001274.5 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001244846.1 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001114122.3 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001114122.2 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001274.5 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38
NM_001274 chr11:g.125643842G>T c.865G>T p.G289* RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References