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Gene | FLT3 |
Variant | D835F |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FLT3 D835F lies within the activation loop in the protein kinase domain of the Flt3 protein (PMID: 25837374). D835F has been associated with FLT3 inhibitor resistance (PMID: 24227820, PMID: 23430109), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, May 2024). |
Associated Drug Resistance | Y |
Category Variants Paths |
FLT3 mutant FLT3 exon20 FLT3 D835X FLT3 D835F |
Transcript | NM_004119.3 |
gDNA | chr13:g.28018504_28018505delGAinsTT |
cDNA | c.2503_2504delGAinsTT |
Protein | p.D835F |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004119.3 | chr13:g.28018504_28018505delGAinsTT | c.2503_2504delGAinsTT | p.D835F | RefSeq | GRCh38/hg38 |
NM_004119.2 | chr13:g.28018504_28018505delGAinsTT | c.2503_2504delGAinsTT | p.D835F | RefSeq | GRCh38/hg38 |
NM_004119 | chr13:g.28018504_28018505delTCinsAA | c.2503_2504delGAinsTT | p.D835F | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 D835F | hematologic cancer | sensitive | Gilteritinib | Preclinical - Cell culture | Actionable | In a preclinical study, Xospata (gilteritinib) resulted in reduced cell viability in transformed cells expressing FLT3 D835F in culture (PMID: 32040554). | 32040554 |