Gene Variant Detail

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Gene FGFR3
Variant K650M
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR3 K650M lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). K650M confers a gain of function to the Fgfr3 protein as demonstrated by ligand-dependent autophosphorylation, activation of Mapk signaling (PMID: 9857065), and activation of Stat1 in kinase assays (PMID: 19088846).
Associated Drug Resistance

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Transcript NM_000142
gDNA chr4:g.1806163A>T
cDNA c.1949A>T
Protein p.K650M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713873 chr4:g.1806163A>T c.1949A>T p.K650M RefSeq GRCh38/hg38
XM_011513422 chr4:g.1806160A>T c.1949A>T p.K650M RefSeq GRCh38/hg38
XM_006713872 chr4:g.1806160A>T c.1949A>T p.K650M RefSeq GRCh38/hg38
NM_000142 chr4:g.1806163A>T c.1949A>T p.K650M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
FGFR3 K650M gain of function FGFR Inhibitor (Pan) FGFR3 Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 K650M Advanced Solid Tumor sensitive PRN1371 Preclinical - Cell culture Actionable In a preclinical study, PRN1371 inhibited proliferation of transformed cells over expressing FGFR3 K650M in culture (PMID: 28978721). 28978721