Gene Variant Detail

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Gene BRAF
Variant N581Y
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF N581Y lies within the protein kinase domain of the Braf protein (UniProt.org). N581Y results in increased cell viability in culture (PMID: 32540409), and therefore, is predicted to lead to a gain of Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF N581X BRAF N581Y

BRAF mutant BRAF act mut BRAF N581Y

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Transcript NM_004333.5
gDNA chr7:g.140754187T>A
cDNA c.1741A>T
Protein p.N581Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004333.5 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38
XM_005250045 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38
NM_004333 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140754187T>A c.1741A>T p.N581Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF N581Y colon cancer resistant GDC0879 Preclinical - Cell culture Actionable In a preclinical study, colon cancer cells harboring BRAF N581Y were resistant to GDC0879 induced growth inhibition in culture (PMID: 19276360). 19276360