Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | BRAF |
Variant | T529N |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | BRAF T529N lies within the protein kinase domain of the Braf protein (UniProt.org). T529N demonstrates RAS-induced kinase activity similar to wild-type Braf in culture (PMID: 20141835), and confers resistance to Raf inhibitors (PMID: 20538618, PMID: 20807807, PMID: 20141835), but has not been fully biochemically characterized and therefore, its effect on Braf protein function is unknown. |
Associated Drug Resistance | Y |
Category Variants Paths |
BRAF mutant BRAF T529N |
Transcript | NM_004333.6 |
gDNA | chr7:g.140777020G>T |
cDNA | c.1586C>A |
Protein | p.T529N |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |