Gene Variant Detail

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Gene BRAF
Variant T529N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF T529N lies within the protein kinase domain of the Braf protein (UniProt.org). T529N demonstrates RAS-induced kinase activity similar to wild-type Braf in culture (PMID: 20141835), and confers resistance to Raf inhibitors (PMID: 20538618, PMID: 20807807, PMID: 20141835), but has not been fully biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Nov 2022).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF T529N

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Transcript NM_004333.5
gDNA chr7:g.140777020G>T
cDNA c.1586C>A
Protein p.T529N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140777020G>T c.1586C>A p.T529N RefSeq GRCh38/hg38
NM_004333 chr7:g.140777020G>T c.1586C>A p.T529N RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140777020G>T c.1586C>A p.T529N RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140777020G>T c.1586C>A p.T529N RefSeq GRCh38/hg38

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
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  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References