Gene Variant Detail

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Gene NRAS
Variant T58I
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS T58I lies within the GTP binding pocket of the Nras protein (UniProt.org). T58I has not been characterized, but can be predicted to confer a loss of function on Nras protein based on the effects of KRAS T58I, which results in defective intrinsic GTPase activity and decreased response to GTPase-activating proteins, leading to increased phosphorylation of of Mek and Akt, and transformation in cell culture (PMID: 16474405).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS T58I

NRAS mutant NRAS exon3 NRAS T58I

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Transcript NM_002524.5
gDNA chr1:g.114713917G>A
cDNA c.173C>T
Protein p.T58I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114713917G>A c.173C>T p.T58I RefSeq GRCh38/hg38
NM_002524 chr1:g.114713917G>A c.173C>T p.T58I RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713917G>A c.173C>T p.T58I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
NRAS T58I loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R