Molecular Profile Detail


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Profile Name BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R
Gene Variant Detail

BRAF V600X (unknown)

MAP2K1 V60E (gain of function)

NRAS Q61R (loss of function)

NRAS T58I (loss of function - predicted)

Relevant Treatment Approaches


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R melanoma predicted - resistant Vemurafenib Clinical Study - Cohort Actionable In a clinical study, a melanoma patient harboring a BRAF V600 mutation developed resistance-associated mutations, MAP2K1 V60E, NRAS T58I, and NRAS Q61R, after 18 weeks of treatment with Zelboraf (vemurafenib) (PMID: 24265153). 24265153
Clinical Trial Phase Therapies Title Recruitment Status