Gene Variant Detail

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Gene FGFR1
Variant A268S
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR1 A268S lies within Ig-like C2-type domain 3 of the Fgfr1 protein (UniProt.org). A268S results in similar cell proliferation and viability levels as wild-type Fgfr1 (PMID: 29533785) and transformation activity similar to wild-type Fgfr1 in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr1 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR1 mutant FGFR1 A268S

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Transcript NM_023110.3
gDNA chr8:g.38424643C>A
cDNA c.802G>T
Protein p.A268S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006716304 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_047421570.1 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
NM_001174063.2 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_017013222.2 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_017013221 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_006716303 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
NM_023110 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
NM_001174063.1 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_017013222 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
NM_001174063 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38424643C>A c.802G>T p.A268S RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 A268S Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A268S were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A268S Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A268S were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A268S Advanced Solid Tumor predicted - resistant E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A268S were resistant to treatment with E7090 in culture (PMID: 34272467). 34272467
FGFR1 A268S Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A268S were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR1 A268S Advanced Solid Tumor predicted - sensitive AZD4547 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 A268S were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467