Gene Variant Detail

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Gene FGFR1
Variant K656N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR1 K656N lies within the protein kinase domain of the Fgfr1 protein (UniProt.org). K656N has been associated with resistance to FGFR inhibitors in culture (PMID: 34114373), and results in increased kinase activity of a truncated Fgfr1 construct in an in vitro assay (PMID: 26864631), but has not been fully biochemically characterized and therefore, its effect on Fgfr1 protein function is unknown.
Associated Drug Resistance Y
Category Variants Paths

FGFR1 mutant FGFR1 K656N

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Transcript NM_023110.3
gDNA chr8:g.38414788C>G
cDNA c.1968G>C
Protein p.K656N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011544449.1 chr8:g.38414196C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_017013221.2 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_006716303 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_017013221.1 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_017013221 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
NM_023110.3 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_011544450 chr8:g.38414196C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_017013226 chr8:g.38414196C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_011544449 chr8:g.38414196C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_006716303.4 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_006716304 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
NM_023110.2 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_011544450.2 chr8:g.38414196C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_017013226.1 chr8:g.38414196C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_006716304.2 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_047421575.1 chr8:g.38415855C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_011544450.3 chr8:g.38414196C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_017013226.2 chr8:g.38414196C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_006716303.3 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_006716304.1 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
NM_023110 chr8:g.38414788C>G c.1968G>C p.K656N RefSeq GRCh38/hg38
XM_011544449.2 chr8:g.38414196C>G c.1968G>C p.K656N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR1 K656N Advanced Solid Tumor predicted - resistant Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 K656N demonstrated insensitivity to Balversa (erdafitinib) in culture (PMID: 34114373). 34114373
FGFR1 K656N Advanced Solid Tumor predicted - sensitive HQP1351 Preclinical - Cell culture Actionable In a preclinical study, GZD824 (HQP1351) inhibited growth of a cell line expressing FGFR1 K656N in culture (PMID: 34114373). 34114373
FGFR1 K656N Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, Truseltiq (infigratinib) inhibited growth of a cell line expressing FGFR1 K656N in culture (PMID: 34114373). 34114373
FGFR1 K656N Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, Lytgobi (futibatinib) inhibited growth of a cell line expressing FGFR1 K656N in culture (PMID: 34114373). 34114373
FGFR1 K656N Advanced Solid Tumor predicted - resistant Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR1 K656N demonstrated insensitivity to Pemazyre (pemigatinib) in culture (PMID: 34114373). 34114373