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Gene RET
Variant V804M
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions RET V804M lies within the protein kinase domain of the Ret protein (UniProt.org). V804M confers a gain of function on the Ret protein, resulting in increased kinase activity, cell transformation (PMID: 16469774), and is considered a gatekeeper due to lack of response to some inhibitors, including cabozantinib and vandetanib (PMID: 23811235, PMID: 27712045).
Associated Drug Resistance Y
Category Variants Paths

RET mutant RET act mut RET V804M

RET mutant RET V804X RET V804M

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Transcript NM_020975.6
gDNA chr10:g.43119548G>A
cDNA c.2410G>A
Protein p.V804M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406744.1 chr10:g.43119548G>A c.2410G>A p.V804M RefSeq GRCh38/hg38
NM_020630 chr10:g.43119548G>A c.2410G>A p.V804M RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43119548G>A c.2410G>A p.V804M RefSeq GRCh38/hg38
NM_001406759.1 chr10:g.43119548G>A c.2410G>A p.V804M RefSeq GRCh38/hg38
NM_020975 chr10:g.43119548G>A c.2410G>A p.V804M RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43119548G>A c.2410G>A p.V804M RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43119548G>A c.2410G>A p.V804M RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43119548G>A c.2410G>A p.V804M RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43119548G>A c.2410G>A p.V804M RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43119548G>A c.2410G>A p.V804M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
RET V804M gain of function RET Inhibitor
RET C634R RET V804M
RET V804M RET S904C
RET V804M RET Y806C
RET V804M RET E805K
RET V804M RET M918T
RET V804M RET G810S RET L881V RET M918T
RET V804M RET G810C RET M918T
RET V804M RET G810S RET M918T
RET V804M RET Y806C RET M918T
RET V804M RET G810S