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|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RET V804M RET Y806C||thyroid gland medullary carcinoma||not applicable||N/A||Guideline||Risk Factor||Compound germline RET V804M and Y806C mutations result in multiple endocrine neoplasia, type 2B (MEN 2B), which is associated with high risk of developing thyroid medullary carcinoma (NCCN.org).||detail...|
|RET V804M RET Y806C||Advanced Solid Tumor||decreased response||Selpercatinib||Preclinical - Biochemical||Actionable||In a preclinical study, transformed human cells expressing RET V804M and Y806C in cis were less sensitive to Retevmo (selpercatinib) in culture (PMID: 35304457).||35304457|