Disease Detail

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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
Unknown unknown Cabozantinib thyroid medullary carcinoma not applicable detail...
Unknown unknown Vandetanib thyroid medullary carcinoma not applicable detail...
RET C634W Sorafenib thyroid medullary carcinoma sensitive detail...
RET M918T Cabozantinib thyroid medullary carcinoma sensitive detail...
RET mutant Everolimus thyroid medullary carcinoma sensitive detail...
RET C620R Everolimus thyroid medullary carcinoma sensitive detail...
RET M918T Everolimus thyroid medullary carcinoma sensitive detail...
Unknown unknown Lenvatinib thyroid medullary carcinoma not applicable detail...
RET C634W XMD15-44 thyroid medullary carcinoma sensitive detail...
RET C634W ALW-II-41-27 thyroid medullary carcinoma sensitive detail...
RET C634W HG-6-63-01 thyroid medullary carcinoma sensitive detail...
RET M918T HG-6-63-01 thyroid medullary carcinoma sensitive detail...
RET M918T XMD15-44 thyroid medullary carcinoma sensitive detail...
RET M918T ALW-II-41-27 thyroid medullary carcinoma sensitive detail...
RET positive Y078-DM4 thyroid medullary carcinoma sensitive detail...
RET M918T AZD1480 thyroid medullary carcinoma sensitive detail...
KDR pos RET C634W Motesanib thyroid medullary carcinoma predicted - sensitive detail...
RET mutant Cabozantinib thyroid medullary carcinoma sensitive detail...
HRAS mutant Cabozantinib thyroid medullary carcinoma sensitive detail...
KRAS mutant Cabozantinib thyroid medullary carcinoma sensitive detail...
Unknown unknown Sorafenib thyroid medullary carcinoma not applicable detail...
RET M918T Sorafenib thyroid medullary carcinoma predicted - sensitive detail...
RET C634R Sorafenib thyroid medullary carcinoma predicted - sensitive detail...
RET C634Y Sorafenib thyroid medullary carcinoma predicted - sensitive detail...
RET C634F Sorafenib thyroid medullary carcinoma predicted - sensitive detail...
RET C618R Sorafenib thyroid medullary carcinoma predicted - sensitive detail...
ATM L804fs ATM S978fs RET M918T Everolimus + Vandetanib thyroid medullary carcinoma predicted - sensitive detail...
RET C634W RXDX-105 thyroid medullary carcinoma sensitive detail...
RET C634W BLU-667 thyroid medullary carcinoma sensitive detail...
RET C609X N/A thyroid medullary carcinoma not applicable detail...
RET C611X N/A thyroid medullary carcinoma not applicable detail...
RET C618X N/A thyroid medullary carcinoma not applicable detail...
RET C620X N/A thyroid medullary carcinoma not applicable detail...
RET C630X N/A thyroid medullary carcinoma not applicable detail...
RET C634X N/A thyroid medullary carcinoma not applicable detail...
RET A883X N/A thyroid medullary carcinoma not applicable detail...
RET M918X N/A thyroid medullary carcinoma not applicable detail...
RET V804M + RET E805K N/A thyroid medullary carcinoma not applicable detail...
RET V804M + RET Y806C N/A thyroid medullary carcinoma not applicable detail...
RET V804M + RET S904C N/A thyroid medullary carcinoma not applicable detail...
RET E768X N/A thyroid medullary carcinoma not applicable detail...
RET L790X N/A thyroid medullary carcinoma not applicable detail...
RET Y791X N/A thyroid medullary carcinoma not applicable detail...
RET V804X N/A thyroid medullary carcinoma not applicable detail...
RET S891X N/A thyroid medullary carcinoma not applicable detail...
RET D631_R635delinsG RET L629P RET V637R BLU-667 thyroid medullary carcinoma predicted - sensitive detail...
RET M918T BLU-667 thyroid medullary carcinoma predicted - sensitive detail...
RET mutant LOXO-292 thyroid medullary carcinoma sensitive detail...
RET V804M LOXO-292 thyroid medullary carcinoma sensitive detail...
RET M918T LOXO-292 thyroid medullary carcinoma sensitive detail...
RET C634W LOXO-292 thyroid medullary carcinoma sensitive detail...
RET M918T RET V804M Everolimus + Vandetanib thyroid medullary carcinoma resistant detail...
RET M918T RET V804M LOXO-292 thyroid medullary carcinoma sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT01396408 Phase II Temsirolimus Sunitinib A Phase II Study of Sunitinib or Temsirolimus in Patients With Advanced Rare Tumours Active, not recruiting
NCT01838642 Phase II Ponatinib Ponatinib for Advanced Medullary Thyroid Cancer Terminated
NCT01896479 FDA approved Cabozantinib A Study of Two Different Doses of Cabozantinib (XL184) in Progressive, Metastatic Medullary Thyroid Cancer Recruiting
NCT02657551 Phase II Regorafenib A Study Using Regorafenib as Second or Third Line Therapy in Metastatic Medullary Thyroid Cancer Recruiting
NCT02831179 Phase I Capecitabine + Temozolomide + Veliparib Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor Withdrawn
NCT02867592 Phase II Cabozantinib Cabozantinib-S-Malate in Treating Younger Patients With Recurrent, Refractory, or Newly Diagnosed Sarcomas, Wilms Tumor, or Other Rare Tumors Recruiting
NCT02936323 PEN-221 PEN-221 in Somatostatin Receptor 2 Expressing Advanced Cancers Including Neuroendocrine and Small Cell Lung Cancers Recruiting
NCT03037385 Phase I BLU-667 Phase 1 Study of BLU-667 in Patients With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors Recruiting
NCT03072160 Phase II Pembrolizumab Pembrolizumab in Recurrent or Metastatic Medullary Thyroid Cancer Recruiting
NCT03157128 Phase Ib/II LOXO-292 Phase 1/2 Study of LOXO-292 in Patients With Advanced Solid Tumors, RET Fusion-Positive Solid Tumors, and Medullary Thyroid Cancer (LIBRETTO-001)ET Activation (LIBRETTO-001)er Recruiting