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Molecular Profile | RET C634W |
Therapy | SYHA1815 |
Indication/Tumor Type | thyroid gland medullary carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
RET C634W | thyroid gland medullary carcinoma | sensitive | SYHA1815 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, SYHA1815 treatment inhibited RET signaling and proliferation of a medullary thyroid cancer cell line harboring RET C634W in culture, and induced tumor regression in a cell line xenograft model (PMID: 34518294). | 34518294 |
PubMed Id | Reference Title | Details |
---|---|---|
(34518294) | The Novel RET Inhibitor SYHA1815 Inhibits RET-Driven Cancers and Overcomes Gatekeeper Mutations by Inducing G1 Cell-Cycle Arrest through c-Myc Downregulation. | Full reference... |