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|RET Inhibitor 52
|SYHA1815 is a selective RET inhibitor with activity against RET V804 mutants, potentially leading to inhibition of cell proliferation and tumor growth (PMID: 34518294).
|thyroid gland medullary carcinoma
|Preclinical - Cell line xenograft
|In a preclinical study, SYHA1815 treatment inhibited RET signaling and proliferation of a medullary thyroid cancer cell line harboring RET C634W in culture, and induced tumor regression in a cell line xenograft model (PMID: 34518294).