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Therapy Name Vepafestinib
Synonyms
Therapy Description

Vepafestinib (TAS0953/HM06) is a selective, ATP-competitive RET inhibitor with activity against RET fusions and V804 and G810 mutants, which may result in decreased tumor cell growth (Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P06-02; Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P233).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Vepafestinib TAS0953/HM06 RET Inhibitor 52 Vepafestinib (TAS0953/HM06) is a selective, ATP-competitive RET inhibitor with activity against RET fusions and V804 and G810 mutants, which may result in decreased tumor cell growth (Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P06-02; Mol Cancer Ther 2021;20(12 Suppl):Abstract nr P233).

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET M918T Advanced Solid Tumor sensitive Vepafestinib Preclinical - Cell culture Actionable In a preclinical study, Vepafestinib (TAS0953/HM06) inhibited proliferation of cells expressing RET M918T in culture (PMID: 37743366). 37743366
RET C634W thyroid gland medullary carcinoma sensitive Vepafestinib Preclinical - Cell culture Actionable In a preclinical study, Vepafestinib (TAS0953/HM06) inhibited proliferation of a medullary thyroid cancer cell line harboring RET C634W in culture (PMID: 37743366). 37743366

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04683250 Phase Ib/II Vepafestinib Study of RET Inhibitor TAS0953/HM06 in Patients With Advanced Solid Tumors With RET Gene Abnormalities ((MARGARET)) Recruiting USA 1


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