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Gene | KIT |
Variant | exon13 |
Impact List | unknown |
Protein Effect | unknown |
Gene Variant Descriptions | KIT exon 13 (amino acids 627-664) indicates an unspecified mutation has occurred in exon 13 of the KIT gene. |
Associated Drug Resistance | |
Category Variants Paths |
KIT mutant KIT exon13 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT exon11 KIT exon13 | gastrointestinal stromal tumor | predicted - sensitive | DCC-3009 | Preclinical | Actionable | In a preclinical study, DCC-3009 induced tumor regression in a xenograft model of gastrointestinal stromal tumor harboring KIT exon 11 and exon 13 mutations (Cancer Res (2023) 83 (7_Supplement): 4033). | detail... |