Disease Detail

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
KIT amp Imatinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown Dovitinib gastrointestinal stromal tumor not applicable detail...
KIT K642E Regorafenib gastrointestinal stromal tumor sensitive detail...
PDGFRA L221F Imatinib gastrointestinal stromal tumor sensitive detail...
KIT positive Imatinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown Regorafenib gastrointestinal stromal tumor not applicable detail...
Unknown unknown Sunitinib gastrointestinal stromal tumor not applicable detail...
Unknown unknown Apatinib gastrointestinal stromal tumor not applicable detail...
KIT act mut Cabozantinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown Pazopanib gastrointestinal stromal tumor not applicable detail...
KIT act mut Pexidartinib gastrointestinal stromal tumor sensitive detail...
KIT D820A KIT V560D Imatinib gastrointestinal stromal tumor resistant detail...
KIT D820A KIT V560D Sunitinib gastrointestinal stromal tumor resistant detail...
KIT mutant N/A gastrointestinal stromal tumor not applicable detail...
PDGFRA mutant N/A gastrointestinal stromal tumor not applicable detail...
KIT exon 9 Sunitinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 11 Sunitinib gastrointestinal stromal tumor decreased response detail...
KIT T670I Imatinib gastrointestinal stromal tumor resistant detail...
KIT V560_L576del Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_L576del Imatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Imatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_L576del KIT V654A Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT T670I Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT T670I Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT D816E Sunitinib gastrointestinal stromal tumor decreased response detail...
KIT V560_Y578del KIT A829P Sunitinib gastrointestinal stromal tumor decreased response detail...
KIT K642E Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT N822K Imatinib gastrointestinal stromal tumor resistant detail...
KIT W557_K558del KIT Y823D Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT K558_V560del KIT W557C Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT P551_W557delinsL Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT M552_K558del Ponatinib gastrointestinal stromal tumor resistant detail...
KIT W557_K558del PD-0325901 gastrointestinal stromal tumor sensitive detail...
Unknown unknown OSI-930 gastrointestinal stromal tumor not applicable detail...
KIT S476I MET R988C Bevacizumab + Sorafenib gastrointestinal stromal tumor sensitive detail...
KIT K642E BGJ398 + Imatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del BGJ398 + Imatinib gastrointestinal stromal tumor sensitive detail...
KIT mutant BGJ398 + Imatinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown Ponatinib gastrointestinal stromal tumor not applicable detail...
KIT exon 11 Imatinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 DCC-2618 gastrointestinal stromal tumor predicted - sensitive detail...
KIT W557_K558del KIT Y823D DCC-2618 gastrointestinal stromal tumor sensitive detail...
Unknown unknown Cediranib gastrointestinal stromal tumor not applicable detail...
KIT exon 11 Ponatinib gastrointestinal stromal tumor predicted - sensitive detail...
Unknown unknown Sorafenib gastrointestinal stromal tumor not applicable detail...
KIT exon 11 Dasatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 11 Nilotinib gastrointestinal stromal tumor sensitive detail...
KIT P551_V555del Sorafenib gastrointestinal stromal tumor sensitive detail...
KIT P551_V555delinsTL Sorafenib gastrointestinal stromal tumor sensitive detail...
PDGFRA D842V Crenolanib gastrointestinal stromal tumor sensitive detail...
PDGFRA D842V Regorafenib gastrointestinal stromal tumor predicted - sensitive detail...
KIT K558_G565delinsR Imatinib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup Imatinib gastrointestinal stromal tumor resistant detail...
KIT P577del KIT W557Lfs*5 KIT D820G Imatinib gastrointestinal stromal tumor resistant detail...
KIT K558_G565delinsR Cabozantinib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup Cabozantinib gastrointestinal stromal tumor sensitive detail...
KIT P577del KIT W557Lfs*5 KIT D820G Cabozantinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
KIT exon 11 KIT A829P Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
KIT exon 11 KIT V654A Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
KIT exon 13 Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
PDGFRA D842X Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 17 Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT mutant DCC-2618 gastrointestinal stromal tumor predicted - sensitive detail...
Unknown unknown Imatinib gastrointestinal stromal tumor not applicable detail...
KIT exon 11 del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
Unknown unknown TAS-116 gastrointestinal stromal tumor not applicable detail...
Unknown unknown PKF118-310 gastrointestinal stromal tumor not applicable detail...
KIT exon 11 Imatinib + PKF118-310 gastrointestinal stromal tumor sensitive detail...
KIT exon 11 Imatinib + XAV939 gastrointestinal stromal tumor sensitive detail...
KIT V559del G007-LK + Imatinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown G007-LK gastrointestinal stromal tumor not applicable detail...
KIT W557_K558del KIT Y823D Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT W557_V559delinsF Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT V654A Avapritinib gastrointestinal stromal tumor sensitive detail...
PDGFRA D842V Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT D820V Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT act mut N/A gastrointestinal stromal tumor not applicable detail...
PDGFRA act mut N/A gastrointestinal stromal tumor not applicable detail...
Unknown unknown DCC-2618 gastrointestinal stromal tumor not applicable detail...
ETV6-NTRK3 Larotrectinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT D816E KIT Y570_L576del PTEN T321fs Imatinib gastrointestinal stromal tumor resistant detail...
KIT D816E KIT Y570_L576del PTEN T321fs Sunitinib gastrointestinal stromal tumor resistant detail...
KIT D816E KIT Y570_L576del PTEN T321fs Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 KIT T670I Imatinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 KIT T670I Sunitinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 11 KIT T670I Regorafenib gastrointestinal stromal tumor predicted - sensitive detail...
KIT A502_Y503dup KIT D820E Imatinib gastrointestinal stromal tumor resistant detail...
KIT A502_Y503dup KIT D820E Sunitinib gastrointestinal stromal tumor predicted - resistant detail...
KIT A502_Y503dup Regorafenib gastrointestinal stromal tumor predicted - sensitive detail...
KIT D816E KIT Y570_L576del PTEN T321fs Imatinib mesylate + LY294002 gastrointestinal stromal tumor sensitive detail...
KIT exon 11 PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 17 PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 11 Pexidartinib + PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 17 Pexidartinib + PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 11 KIT exon 17 PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT P577del KIT W557Lfs*5 KIT D820G PLX9486 gastrointestinal stromal tumor sensitive detail...
Unknown unknown Dasatinib gastrointestinal stromal tumor not applicable detail...
PDGFRA D842V Dasatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT D820N Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT D816E KIT D820V Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V555_L576del KIT D820G KIT D820Y Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT A502_Y503dup KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT K558_V560del KIT V654A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558delinsCE KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V559A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V569_L576del KIT V654A KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT Y553S KIT V556_T574del KIT D820Y Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT A502_Y503dup PDGFRA H687Y Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT mutant Avapritinib gastrointestinal stromal tumor predicted - sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT00290485 Phase II Imatinib Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST) Unknown status
NCT00812240 Phase III Masitinib Imatinib A Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Comparison to Imatinib in Patients With Gastro-Intestinal Stromal Tumour in First Line Medical Treatment Terminated
NCT01396148 Phase II Sunitinib A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor Completed
NCT01643278 Phase I Dasatinib + Ipilimumab Dasatinib and Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumors or Other Sarcomas That Cannot Be Removed by Surgery or Are Metastatic Completed
NCT01738139 Phase I Ipilimumab + Imatinib Mesylate Ipilimumab and Imatinib Mesylate in Advanced Cancer Recruiting
NCT01874665 Phase II Ponatinib A Phase 2 Trial of Ponatinib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor Completed
NCT01991379 Phase Ib/II MEK162 + Imatinib mesylate MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST) Recruiting
NCT02015065 Phase II Vandetanib Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors Active, not recruiting
NCT02034110 Phase II Trametinib + Dabrafenib Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers Active, not recruiting
NCT02071862 Phase I CB-839 Study of the Glutaminase Inhibitor CB-839 in Solid Tumors Active, not recruiting
NCT02122809 Phase I Chiauranib Phase I Study of Chiauranib in Patients With Advanced Solid Tumors Completed
NCT02164240 Phase I Sunitinib Regorafenib Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GIST Active, not recruiting
NCT02232620 Phase II BBI503 A Study of BBI503 in Adult Patients With Advanced Gastrointestinal Stromal Tumors Active, not recruiting
NCT02257541 Phase Ib/II BGJ398 + Imatinib BGJ398 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST) Active, not recruiting
NCT02401815 Phase Ib/II PLX9486 + Sunitinib Pexidartinib + PLX9486 PLX9486 A Study of PLX9486 as a Single Agent and in Combination With PLX3397 in Patients With Advanced Solid Tumors Including GIST Active, not recruiting
NCT02508532 Phase I Avapritinib Phase 1 Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors Recruiting
NCT02574663 Phase I Nab-paclitaxel + Gemcitabine Bevacizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Umbralisib TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors Active, not recruiting
NCT02847429 Phase III Crenolanib Randomized Trial of Crenolanib in Subjects With D842V Mutated GIST Recruiting
NCT02880020 Phase II Nivolumab Nivolumab + Ipilimumab Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgery Recruiting
NCT03109301 Phase II Selumetinib A Phase II Trial of the Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Patients With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) Recruiting
NCT03158103 Phase I Binimetinib + Pexidartinib A Study of MEK162 (Binimetinib) in Combination With Pexidartinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST) Active, not recruiting
NCT03165721 Phase II Guadecitabine A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer Recruiting
NCT03291054 Phase II Epacadostat + Pembrolizumab Epacadostat and Pembrolizumab in Patients With GIST Recruiting
NCT03353753 Phase III DCC-2618 Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies (invictus) Active, not recruiting
NCT03411915 Phase I XmAb18087 A Study of XmAb18087 in Subjects With NET and GIST Recruiting
NCT03465722 Phase III Regorafenib Avapritinib (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST Recruiting
NCT03673501 Phase III Sunitinib DCC-2618 A Study of DCC-2618 vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib (intrigue) Recruiting