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Molecular Profile Therapy Indication/Tumor Type Response Type Profile Response Detail
KIT amp Imatinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown Dovitinib gastrointestinal stromal tumor not applicable detail...
KIT K642E Regorafenib gastrointestinal stromal tumor sensitive detail...
PDGFRA L221F Imatinib gastrointestinal stromal tumor sensitive detail...
KIT positive Imatinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown Regorafenib gastrointestinal stromal tumor not applicable detail...
Unknown unknown Sunitinib gastrointestinal stromal tumor not applicable detail...
Unknown unknown Rivoceranib gastrointestinal stromal tumor not applicable detail...
KIT act mut Cabozantinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown Pazopanib gastrointestinal stromal tumor not applicable detail...
KIT act mut Pexidartinib gastrointestinal stromal tumor sensitive detail...
KIT V560D KIT D820A Imatinib gastrointestinal stromal tumor resistant detail...
KIT V560D KIT D820A Sunitinib gastrointestinal stromal tumor resistant detail...
KIT mutant N/A gastrointestinal stromal tumor not applicable detail...
PDGFRA mutant N/A gastrointestinal stromal tumor not applicable detail...
KIT exon9 Sunitinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 Sunitinib gastrointestinal stromal tumor decreased response detail...
KIT T670I Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V560_L576del Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_L576del Imatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Imatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_L576del KIT V654A Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT T670I Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT T670I Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT D816E Sunitinib gastrointestinal stromal tumor decreased response detail...
KIT V560_Y578del KIT A829P Sunitinib gastrointestinal stromal tumor decreased response detail...
KIT K642E Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del KIT Y823D Ponatinib gastrointestinal stromal tumor sensitive detail...
KIT W557C KIT K558_V560del Ponatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT P551_W557delinsL Ponatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT M552_K558del Ponatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del PD-0325901 gastrointestinal stromal tumor sensitive detail...
Unknown unknown OSI-930 gastrointestinal stromal tumor not applicable detail...
KIT K642E Imatinib + Infigratinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Imatinib + Infigratinib gastrointestinal stromal tumor sensitive detail...
KIT mutant Imatinib + Infigratinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown Ponatinib gastrointestinal stromal tumor not applicable detail...
KIT exon11 Imatinib gastrointestinal stromal tumor sensitive detail...
KIT exon11 Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon11 Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT Y823D Ripretinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown Cediranib gastrointestinal stromal tumor not applicable detail...
KIT exon11 Ponatinib gastrointestinal stromal tumor predicted - sensitive detail...
Unknown unknown Sorafenib gastrointestinal stromal tumor not applicable detail...
KIT exon11 Dasatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 Nilotinib gastrointestinal stromal tumor sensitive detail...
KIT P551_V555del Sorafenib gastrointestinal stromal tumor sensitive detail...
KIT P551_V555delinsTL Sorafenib gastrointestinal stromal tumor sensitive detail...
PDGFRA D842V Crenolanib gastrointestinal stromal tumor sensitive detail...
PDGFRA D842V Regorafenib gastrointestinal stromal tumor predicted - sensitive detail...
KIT K558_G565delinsR Imatinib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup Imatinib gastrointestinal stromal tumor resistant detail...
KIT W557Lfs*5 KIT P577del KIT D820G Imatinib gastrointestinal stromal tumor resistant detail...
KIT K558_G565delinsR Cabozantinib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup Cabozantinib gastrointestinal stromal tumor sensitive detail...
KIT W557Lfs*5 KIT P577del KIT D820G Cabozantinib gastrointestinal stromal tumor sensitive detail...
KIT exon11 Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
KIT exon11 KIT A829P Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
KIT exon11 KIT V654A Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
KIT exon13 Imatinib + MK2206 gastrointestinal stromal tumor sensitive detail...
PDGFRA D842X Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon17 Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT mutant Ripretinib gastrointestinal stromal tumor predicted - sensitive detail...
Unknown unknown Imatinib gastrointestinal stromal tumor not applicable detail...
KIT exon 11 del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
Unknown unknown Pimitespib gastrointestinal stromal tumor not applicable detail...
Unknown unknown PKF118-310 gastrointestinal stromal tumor not applicable detail...
KIT exon11 Imatinib + PKF118-310 gastrointestinal stromal tumor sensitive detail...
KIT exon11 Imatinib + XAV939 gastrointestinal stromal tumor sensitive detail...
KIT V560del G007-LK + Imatinib gastrointestinal stromal tumor sensitive detail...
Unknown unknown G007-LK gastrointestinal stromal tumor not applicable detail...
KIT W557_K558del KIT Y823D Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT W557_V559delinsF Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT V654A Avapritinib gastrointestinal stromal tumor sensitive detail...
PDGFRA D842V Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT D820V Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT act mut N/A gastrointestinal stromal tumor not applicable detail...
PDGFRA act mut N/A gastrointestinal stromal tumor not applicable detail...
Unknown unknown Ripretinib gastrointestinal stromal tumor not applicable detail...
ETV6 - NTRK3 Larotrectinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 KIT T670I Imatinib gastrointestinal stromal tumor resistant detail...
KIT exon11 KIT T670I Sunitinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 KIT T670I Regorafenib gastrointestinal stromal tumor predicted - sensitive detail...
KIT A502_Y503dup KIT D820E Imatinib gastrointestinal stromal tumor resistant detail...
KIT A502_Y503dup KIT D820E Sunitinib gastrointestinal stromal tumor predicted - resistant detail...
KIT A502_Y503dup Regorafenib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon17 PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 Pexidartinib + PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon17 Pexidartinib + PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon11 KIT exon17 PLX9486 gastrointestinal stromal tumor predicted - sensitive detail...
KIT W557Lfs*5 KIT P577del KIT D820G PLX9486 gastrointestinal stromal tumor sensitive detail...
Unknown unknown Dasatinib gastrointestinal stromal tumor not applicable detail...
PDGFRA D842V Dasatinib gastrointestinal stromal tumor sensitive detail...
KIT D820N Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558del KIT D816E KIT D820V Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V555_L576del KIT D820G KIT D820Y Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT A502_Y503dup KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT K558_V560del KIT V654A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT W557_K558delinsCE KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V559A Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V569_L576del KIT V654A KIT N822K Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT Y553S KIT V556_T574del KIT D820Y Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT A502_Y503dup PDGFRA H687Y Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT mutant Avapritinib gastrointestinal stromal tumor predicted - sensitive detail...
Unknown unknown JSH-150 gastrointestinal stromal tumor not applicable detail...
KIT V560_Y578del KIT V654A AZD3229 gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT V654A AZD3229 gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT Y823D AZD3229 gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del HQP1351 gastrointestinal stromal tumor sensitive detail...
KIT exon9 Imatinib gastrointestinal stromal tumor sensitive detail...
PDGFRA D842V Imatinib gastrointestinal stromal tumor resistant detail...
PDGFRA mutant Imatinib gastrointestinal stromal tumor sensitive detail...
PDGFRA H845_N848delinsP Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V560_Y578del Axitinib gastrointestinal stromal tumor sensitive detail...
KIT K642E Axitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT T670I Axitinib gastrointestinal stromal tumor sensitive detail...
KIT V559D Axitinib gastrointestinal stromal tumor sensitive detail...
KIT K642E Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Sunitinib gastrointestinal stromal tumor sensitive detail...
PDGFRA D846V Imatinib gastrointestinal stromal tumor predicted - resistant detail...
MLH1 M524I PDGFRA W559_R560del Imatinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT V654A Avapritinib gastrointestinal stromal tumor predicted - resistant detail...
KIT T670I Avapritinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V560D Avapritinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT exon 11 del Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del Midostaurin gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT T670I Ripretinib gastrointestinal stromal tumor decreased response detail...
KIT exon 11 del KIT T670I Imatinib gastrointestinal stromal tumor resistant detail...
KIT exon 11 del KIT T670I Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT T670I Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT T670I Midostaurin gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT T670I Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816E Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816E Midostaurin gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816E Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816E Sunitinib gastrointestinal stromal tumor decreased response detail...
KIT exon 11 del KIT D816E Imatinib gastrointestinal stromal tumor sensitive detail...
KIT exon 11 del KIT D816E Ripretinib gastrointestinal stromal tumor sensitive detail...
KIT V559_G565del KIT V654A KIT A829P Ripretinib gastrointestinal stromal tumor predicted - sensitive detail...
KIT Y568_L576delinsCV KIT D816E KIT D820Y Ripretinib gastrointestinal stromal tumor predicted - sensitive detail...
CDKN2A del Palbociclib gastrointestinal stromal tumor no benefit detail...
PDGFRA exon18 Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT V560_L576del KIT V654A HQP1351 gastrointestinal stromal tumor sensitive detail...
KIT W557Lfs*5 KIT P577del KIT D820G Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT A502_Y503dup Avapritinib gastrointestinal stromal tumor sensitive detail...
PDGFRA V561D PDGFRA D842V Imatinib gastrointestinal stromal tumor resistant detail...
KIT K642E KIT C809G KIT N822H Imatinib gastrointestinal stromal tumor predicted - resistant detail...
KIT K642E KIT N822K AZD3229 gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT Y823D Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT K642E KIT N822K Regorafenib gastrointestinal stromal tumor sensitive detail...
KIT W557_K558del KIT V654A Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT V654A Sunitinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del KIT V654A Ripretinib gastrointestinal stromal tumor predicted - resistant detail...
KIT V560_Y578del KIT V654A Avapritinib gastrointestinal stromal tumor resistant detail...
KIT V560_Y578del KIT V654A Imatinib gastrointestinal stromal tumor resistant detail...
KIT V560_Y578del KIT V654A Regorafenib gastrointestinal stromal tumor resistant detail...
KIT V560_Y578del AZD3229 gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Avapritinib gastrointestinal stromal tumor sensitive detail...
KIT V560_Y578del Ripretinib gastrointestinal stromal tumor resistant detail...
KIT V560_Y578del Regorafenib gastrointestinal stromal tumor sensitive detail...
Clinical Trial Phase Therapies Title Recruitment Status
NCT00290485 Phase II Imatinib Gleevec Administered Preoperatively to Reduce Gastrointestinal Stromal Tumor (GIST) Unknown status
NCT00812240 Phase III Masitinib Imatinib A Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Comparison to Imatinib in Patients With Gastro-Intestinal Stromal Tumour in First Line Medical Treatment Terminated
NCT01396148 Phase II Sunitinib A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor Completed
NCT01643278 Phase I Dasatinib + Ipilimumab Dasatinib and Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumors or Other Sarcomas That Cannot Be Removed by Surgery or Are Metastatic Completed
NCT01738139 Phase I Imatinib + Ipilimumab Ipilimumab and Imatinib Mesylate in Advanced Cancer Recruiting
NCT01874665 Phase II Ponatinib A Phase 2 Trial of Ponatinib in Patients With Metastatic and/or Unresectable Gastrointestinal Stromal Tumor Completed
NCT01991379 Phase Ib/II Binimetinib + Imatinib MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST) Recruiting
NCT02015065 Phase II Vandetanib Phase II Trial of Vandetanib in Children and Adults With Wild-Type Gastrointestinal Stromal Tumors Completed
NCT02034110 Phase II Dabrafenib + Trametinib Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers Active, not recruiting
NCT02071862 Phase I Everolimus + Telaglenastat Erlotinib + Telaglenastat Docetaxel + Telaglenastat Telaglenastat Paclitaxel + Telaglenastat Cabozantinib + Telaglenastat Study of the Glutaminase Inhibitor CB-839 in Solid Tumors Completed
NCT02122809 Phase I Chiauranib Phase I Study of Chiauranib in Patients With Advanced Solid Tumors Completed
NCT02164240 Phase I Sunitinib Regorafenib Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GIST Active, not recruiting
NCT02232620 Phase II BBI503 A Study of BBI503 in Adult Patients With Advanced Gastrointestinal Stromal Tumors Terminated
NCT02257541 Phase Ib/II Imatinib + Infigratinib BGJ398 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST) Completed
NCT02401815 Phase Ib/II PLX9486 + Sunitinib Pexidartinib + PLX9486 PLX9486 PLX9486 as a Single Agent and in Combination With PLX3397 or PLX9486 With Sunitinib in Patients With Advanced Solid Tumors Completed
NCT02508532 Phase I Avapritinib Phase 1 Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors Active, not recruiting
NCT02574663 Phase I Gemcitabine + Nab-paclitaxel Bevacizumab Fluorouracil + Leucovorin + Oxaliplatin + Pembrolizumab Umbralisib TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors Completed
NCT02847429 Phase III Crenolanib Randomized Trial of Crenolanib in Subjects With D842V Mutated GIST Recruiting
NCT02880020 Phase II Nivolumab Ipilimumab + Nivolumab Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgery Recruiting
NCT03109301 Phase II Selumetinib A Phase II Trial of the Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Patients With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST) Withdrawn
NCT03158103 Phase I Binimetinib + Pexidartinib A Study of MEK162 (Binimetinib) in Combination With Pexidartinib in Patients With Advanced Gastrointestinal Stromal Tumor (GIST) Active, not recruiting
NCT03165721 Phase II Guadecitabine A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer Completed
NCT03291054 Phase II Epacadostat + Pembrolizumab Epacadostat and Pembrolizumab in Patients With GIST Active, not recruiting
NCT03353753 Phase III Ripretinib Phase 3 Study of DCC-2618 vs Placebo in Advanced GIST Patients Who Have Been Treated With Prior Anticancer Therapies (invictus) Active, not recruiting
NCT03411915 Phase I XmAb18087 A Study of XmAb18087 in Subjects With NET and GIST Recruiting
NCT03465722 Phase III Regorafenib Avapritinib (VOYAGER) Study of Avapritinib vs Regorafenib in Patients With Locally Advanced Unresectable or Metastatic GIST Active, not recruiting
NCT03556384 Phase II Temozolomide Temozolomide (TMZ) In Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST) Recruiting
NCT03673501 Phase III Sunitinib Ripretinib A Study of DCC-2618 vs Sunitinib in Advanced GIST Patients After Treatment With Imatinib (intrigue) Recruiting
NCT04000529 Phase I Spartalizumab + TNO155 Ribociclib + TNO155 Phase Ib Study of TNO155 in Combination With Spartalizumab or Ribociclib in Selected Malignancies Recruiting
NCT04276415 Phase I DS-6157a DS-6157a in Participants With Advanced Gastrointestinal Stromal Tumor (GIST) Recruiting