Molecular Profile Detail


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Profile Name KIT E562_L576del
Gene Variant Detail

KIT E562_L576del (gain of function - predicted)

Relevant Treatment Approaches KIT Inhibitor


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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT E562_L576del gastrointestinal stromal tumor predicted - sensitive KIT Inhibitor Binimetinib + Imatinib Case Reports/Case Series Actionable In a Phase II trial, Gleevec (imatinib) and Mektovi (binimetinib) combination treatment resulted in an 80% pathological response and 23% RECIST response in a patient with a small bowel gastrointestinal stromal tumor harboring KIT E562_L576del (PMID: 35041493; NCT01991379). 35041493