Therapy Detail

Therapy Name BBI503
Synonyms
Therapy Description

Amcasertib (BBI503) is a kinase inhibitor that inhibits signaling pathways that regulate survival of cancer stem cells, resulting in decreased cancer cell growth (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BBI503 Amcasertib BBI-503 Amcasertib (BBI503) is a kinase inhibitor that inhibits signaling pathways that regulate survival of cancer stem cells, resulting in decreased cancer cell growth (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status
NCT02232620 Phase II BBI503 A Study of BBI503 in Adult Patients With Advanced Gastrointestinal Stromal Tumors Terminated
NCT02483247 Phase Ib/II Paclitaxel Doxorubicin Capecitabine Nivolumab Sunitinib Pembrolizumab BBI503 A Study of BBI503 in Combination With Selected Anti-Cancer Therapeutics in Adult Patients With Advanced Cancer Active, not recruiting
NCT01781455 Phase Ib/II BBI503 A Study of BBI503 in Adult Patients With Advanced Solid Tumors Active, not recruiting
NCT02432326 Phase I BBI503 Napabucasin A Study of BBI608 and BBI503 Administered in Combination to Adult Patients With Advanced Solid Tumors Active, not recruiting
NCT02232633 Phase II BBI503 A Study of BBI503 in Adult Patients With Advanced Hepatobiliary Cancer Active, not recruiting
NCT02432690 Phase II BBI503 A Study of BBI503 in Asymptomatic Recurrent Ovarian Cancer Patients With CA-125 Elevation Terminated


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