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Gene | CHEK1 |
Variant | over exp |
Impact List | none |
Protein Effect | no effect |
Gene Variant Descriptions | CHEK1 over exp indicates an over expression of the Chek1 protein and/or mRNA. However, the mechanism causing the over expression is unspecified. |
Associated Drug Resistance | |
Category Variants Paths |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CHEK1 over exp | lung small cell carcinoma | sensitive | PF-00477736 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, small cell lung cancer cell lines, which expressed high levels of CHEK1, demonstrated sensitivity to PF-00477736 treatment, resulting in decreased viability in culture and reduced tumor growth in xenograft models (PMID: 29138515). | 29138515 |
CHEK1 over exp | lung small cell carcinoma | sensitive | Berzosertib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, small cell lung cancer cell lines, which expressed high levels of CHEK1, demonstrated sensitivity to Berzosertib (VX-970) treatment, resulting in decreased viability in culture and reduced tumor growth in xenograft models (PMID: 29138515). | 29138515 |