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|Gene Variant Descriptions||ALK C990R lies within the extracellular domain of the Alk protein (UniProt.org). C990R increased cell proliferation and cell viability compared to wild-type Alk in one of two cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Alk protein function is unknown (PubMed, Oct 2022).|
|Associated Drug Resistance|
|Category Variants Paths||
ALK mutant ALK C990R
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|