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Gene | ALK |
Variant | S711R |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | ALK S711R lies within the extracellular domain of the Alk protein (UniProt.org). S711R has not been biochemically characterized, but results in similar cell proliferation and viability levels to wild-type Alk in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Alk protein function. |
Associated Drug Resistance | |
Category Variants Paths |
ALK mutant ALK S711R |
Transcript | NM_004304.5 |
gDNA | chr2:g.29251176G>C |
cDNA | c.2133C>G |
Protein | p.S711R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004304.5 | chr2:g.29251176G>C | c.2133C>G | p.S711R | RefSeq | GRCh38/hg38 |
NM_004304 | chr2:g.29251176G>C | c.2133C>G | p.S711R | RefSeq | GRCh38/hg38 |
NM_004304.4 | chr2:g.29251176G>C | c.2133C>G | p.S711R | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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