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Gene FGFR2
Variant V392M
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 V392M lies within the helical domain of the Fgfr2 protein (UniProt.org). V392M has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 in cultured cells (PMID: 29533785), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 V392M

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Transcript NM_000141.5
gDNA chr10:g.121515230C>T
cDNA c.1174G>A
Protein p.V392M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38
XM_024447888.2 chr10:g.121503840_121503842delGTCinsATG c.1174_1176delGTCinsATG p.V392M RefSeq GRCh38/hg38
XM_024447888.1 chr10:g.121503840_121503842delGTCinsATG c.1174_1176delGTCinsATG p.V392M RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38
XM_017015922 chr10:g.121503840_121503842delGACinsCAT c.1174_1176delGTCinsATG p.V392M RefSeq GRCh38/hg38
NM_000141 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121515230C>T c.1174G>A p.V392M RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References