Gene Detail

Gene Symbol FGFR2
Synonyms BBDS | BEK | BFR-1 | CD332 | CEK3 | CFD1 | ECT1 | JWS | K-SAM | KGFR | TK14 | TK25
Gene Description FGFR2 is a receptor tyrosine kinase activated upon binding of the FGF ligand, which activates RAS-MAPK and PI3K-AKT pathways. Altered function of FGFR2 in cancer may lead to increased cell proliferation and decreased apoptosis (PMID: 22508544).
Entrez Id 2263
Chromosome 10
Map Location 10q26.13
Canonical Transcript NM_000141

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Variant Impact Protein Effect Variant Description Associated with drug Resistance
D530N missense loss of function FGFR2 D530N lies within the protein kinase domain of the FGFR2 protein (PMID: 19147536). D530N confers a loss of function to the FGFR2 protein resulting in a loss of protein kinase activity and reduced downstream MAPK signaling pathway activation (PMID: 19147536).
R330W missense unknown FGFR2 R330W lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). R330W has been identified in sequencing studies (PMID: 22197931), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
A264T missense unknown FGFR2 A264T lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). A264T has been identified in the scientific literature (PMID: 26645239), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
V564T missense no effect - predicted FGFR2 V564T lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V564T is predicted to have no effect on Fgfr2 protein function as it demonstrates activation rates similar to wild-type Fgfr2, but has also been demonstrated to confer resistance to Fgfr inhibitors in culture (PMID: 21454610). Y
FGFR2 - ZMYM4 fusion unknown FGFR2-ZMYM4 results from the fusion of FGFR2 and ZMYM4 (PMID: 28034880). FGFR2-ZMYM4 has been identified in intrahepatic cholangiocarcinoma (PMID: 28034880), but has not been biochemically characterized and therefore, the effect on fusion protein function is unknown (PubMed, Nov 2018).
G583V missense unknown FGFR2 G583V lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). G583V has been identified in sequencing studies (PMID: 22980975, PMID: 26960398), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
Q620K missense unknown FGFR2 Q620K lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). Q620K has been identified in sequencing studies (PMID: 25035393, PMID: 29106415), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
D138N missense unknown FGFR2 D138N does not lie within any known functional domains of the Fgfr2 protein (UniProt.org). D138N has been identified in the scientific literature (PMID: 17360555), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
T370R missense unknown FGFR2 T370R lies within the extracellular domain of the Fgfr2 protein (UniProt.org). T370R has been identified in sequencing studies (PMID: 19147536), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
D283N missense unknown FGFR2 D283N lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). D283N has been identified in sequencing studies (PMID: 16140923), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
I590M missense unknown FGFR2 I590M lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). I590M has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
Y281C missense unknown FGFR2 Y281C lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). Y281C has been identified in sequencing studies (PMID: 11781872), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
act mut unknown gain of function FGFR2 act mut indicates that this variant results in a gain of function in the FGFR2 protein. However, the specific amino acid change has not been identified.
K659M missense unknown FGFR2 K659M lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K659M has been identified in sequencing studies (PMID: 28034880, PMID: 18552176), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
E731K missense unknown FGFR2 E731K lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E731K may confer a gain of function to the Fgfr2 protein as demonstrated by increased phosphorylation of Fgfr2, Erk signaling, and transcriptional activation of Runx2 in culture (PMID: 21928350), however in another study, E731K results in similar cell proliferation and viability levels as wild-type Fgfr2, in two different cell lines (PMID: 29533785).
M537I missense unknown FGFR2 M537I lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M537I has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
L772F missense unknown FGFR2 L772F lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). L772F has been identified in the scientific literature (PMID: 26003532), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
M536I missense gain of function FGFR2 M536I (corresponds to M535I in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M536I results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
W290C missense gain of function FGFR2 W290C lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). W290C does not result in increased Fgfr2 phosphorylation, but increases both ligand-dependent and ligand-independent dimerization of Fgfr2, is transforming in cell culture, and promotes tumor formation in xenograft models (PMID: 23786770).
I642T missense unknown FGFR2 I642T lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). I642T has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
C278F missense unknown FGFR2 C278F lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). C278F results in increased Fgfr2 dimerization and autophosphorylation, however, it also leads to rapid FGFR2 degradation (PMID: 16844695), impaired Erk and TGF-beta signaling, and decreased cell viability in culture (PMID: 20004243) and therefore, its effect on the Fgfr2 protein function is unknown.
Y588D missense unknown FGFR2 Y588D lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). Y588D has been identified in sequencing studies (PMID: 25669975), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
R165W missense unknown FGFR2 R165W lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). R165W has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
G302W missense unknown FGFR2 G302W lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). G302W has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
R251Q missense loss of function FGFR2 R251Q lies within the region linking Ig-like domains II and III of the Fgfr2 protein (PMID: 11121055). R251Q results in loss of ligand binding and diminished Mapk activation upon Fgf2 stimulation in cell culture (PMID: 19147536).
F276C missense gain of function FGFR2 F276C lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniPort.org). F276C results in increased Fgfr2 expression, altered cellular localization, and ligand-independent Erk phosphorylation in culture (JCO Precis Oncol 2017:1, 1-13).
M584V missense unknown FGFR2 M584V lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M584V has been identified in sequencing studies (PMID: 22960745), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
S57L missense unknown FGFR2 S57L lies within the Ig-like C2-type domain 1 of the Fgfr2 protein (UniProt.org). S57L has been identified in sequencing studies (PMID: 11781872, PMID: 24728327), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
FGFR2 - PPHLN1 fusion gain of function FGFR2-PPHLN1 results from the fusion of FGFR2 and PPHLN1 (PMID: 25608663), resulting in constitutive activation of the fusion protein and activation of downstream Erk1/2 signaling (PMID: 25608663).
E566G missense gain of function FGFR2 E566G (corresponds to E565G in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E566G results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
FGFR2 - CCAR2 fusion unknown FGFR2-CCAR2 (also referred to as FGFR2-KIAA1967) results from the fusion of FGFR2 and CCAR2 (PMID: 23558953). FGFR2-CCAR2 has been identified in lung cancer (PMID: 27245147, PMID: 23558953), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Nov 2018).
FGFR2 - CASP7 fusion unknown FGFR2-CASP7 results from the fusion of FGFR2 and CASP7 (PMID: 23558953). FGFR2-CASP7 has been identified in breast cancer (PMID: 23558953), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Nov 2018).
A97T missense unknown FGFR2 A97T lies within the Ig-like C2-type domain 1 of the Fgfr2 protein (UniProt.org). A97T has been identified in sequencing studies (PMID: 28581676, PMID: 18552176), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
E116K missense unknown FGFR2 E116K lies within the Ig-like C2-type domain 1 of the Fgfr2 protein (UniProt.org). E116K has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
D602E missense unknown FGFR2 D602E lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). D602E has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
dec exp none no effect FGFR2 dec exp indicates decreased expression of the Fgfr2 protein and/or mRNA. However, the mechanism causing the decreased expression is unspecified.
over exp none no effect FGFR2 over exp indicates an over expression of the Fgfr2 protein and/or mRNA. However, the mechanism causing the over expression is unspecified.
S354C missense unknown FGFR2 S354C lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). S354C has been identified in sequencing studies (PMID: 8528214), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
S799A missense no effect - predicted FGFR2 S799A does not lie within any known functional domains of the Fgfr2 protein (UniProt.org). S799A has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785) and therefore, is predicted to have no effect on Fgfr2 protein function.
E636* nonsense loss of function - predicted FGFR2 E636* results in the premature truncation within the kinase domain of the Fgfr2 at amino acid 636 of 821 (UniProt.org). Due to the disruption of the protein kinase domain (UniProt.org), E636* is predicted to lead to a loss of function.
D101Y missense gain of function - predicted FGFR2 D101Y lies within the extracellular Ig-like C2-type domain 1 of the Fgfr2 protein (UniProt.org). D101Y results in the transformation of cells in culture (PMID: 18552176) and therefore, is predicted to result in a gain of FGFR2 protein function.
S347C missense unknown FGFR2 S347C lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). S347C has been identified in sequencing studies (PMID: 12544231), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
T730S missense no effect FGFR2 T730S (corresponds to T729S in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). T730S has activity similar to wild-type Fgfr2 as demonstrated by equivalent substrate phosphorylation and the lack of oncogenic cell transformation (PMID: 26048680).
R203C missense gain of function FGFR2 R203C lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). R203C results in increased phosphorylation of Fgfr2 and activation of Mek signaling in cell culture (PMID: 23527311).
E596K missense unknown FGFR2 E596K lies within the protein kinase domain if the Fgfr2 protein (UniProt.org). E596K has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
C342F missense unknown FGFR2 C342F lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). C342F has been identified in sequencing studies (PMID: 11781872), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
E636K missense unknown FGFR2 E636K lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E636K has been identified in the scientific literature (PMID: 19147536), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
E160A missense unknown FGFR2 E160A lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). E160A has not been biochemically characterized, but is predicted to disrupt Fgfr2-heparan sulfate interaction and Fgfr dimerization based on structural modeling (PMID: 19147536).
S267P missense unknown FGFR2 S267P lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). S267P has been identified in sequencing studies (PMID: 11325814), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
Y340C missense unknown FGFR2 Y340C lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). Y340C has been identified in sequencing studies (PMID: 16418739), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
Q289P missense unknown FGFR2 Q289P lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). Q289P has been identified in sequencing studies (PMID: 19066959, PMID: 16526917), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
P303L missense unknown FGFR2 P303L lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniPort.org). P303L has been identified in the scientific literature (PMID: 19812598), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
K526E missense gain of function - predicted FGFR2 K526E lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K526E results in increased Fgfr2 autophosphorylation in an in vitro assay (PMID: 17803937) and therefore, is predicted to result in a gain of Fgfr2 protein function.
L618M missense gain of function FGFR2 L618M (corresponds to L617M in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L618M results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
E695K missense unknown FGFR2 E695K lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E695K has been identified in sequencing studies (PMID: 24265153, PMID: 28481359), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
mutant unknown unknown FGFR2 mutant indicates an unspecified mutation in the FGFR2 gene.
R6P missense unknown FGFR2 R6P lies within the signaling peptide region of the Fgfr2 protein (UniProt.org). R6P has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
M538R missense unknown FGFR2 M538R lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M538R has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
W290_I291delinsC indel gain of function FGFR2 W290_I291delinsC results in a deletion of tryptophan (W) at amino acid 290 and isoleucine (I) at amino acid 291 within the Ig3 region of Fgfr2, combined with the insertion of a cysteine (C) at the same site (UniProt.org). W290_I291delinsC confers a gain of function on Fgfr2 as demonstrated by ligand-independent phosphorylation, dimerization, and oncogenic transformation (PMID: 26048680).
A315S missense unknown FGFR2 A315S lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). A315S has been identified in sequencing studies (PMID: 17525745), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
G183fs frameshift loss of function - predicted FGFR2 G183fs results in a change in the amino acid sequence of the Fgfr2 protein beginning at aa 183 of 821, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), G183fs is predicted to lead to a loss of Fgfr2 function.
G384E missense unknown FGFR2 G384E lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). G384E has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
N549T missense gain of function FGFR2 N549T lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N549T results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937).
C382Y missense no effect - predicted FGFR2 C382Y lies within the helical domain of the Fgfr2 protein (UniProt.org). C382Y has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785).
G663E missense gain of function FGFR2 G663E lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). G663E results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937).
V77M missense unknown FGFR2 V77M lies within the Ig-like C2-type domain 1 of the Fgfr2 protein (UniProt.org). V77M has been identified in the scientific literature (PMID: 19147536), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
G271E missense loss of function FGFR2 G271E lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). G271E confers a loss of function to the Fgfr2 protein as indicated by impaired receptor processing and decreased cell proliferation as compared to wild-type Fgfr2 in culture (PMID: 19147536).
V564M missense unknown FGFR2 V564M lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V564M has been demonstrated to confer resistance to Fgfr inhibitors in cell culture (PMID: 28034880), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Jun 2018). Y
inact mut unknown loss of function FGFR2 inact mut indicates that this variant results in a loss of function of the Fgfr2 protein. However, the specific amino acid change has not been identified.
N549H missense gain of function FGFR2 N549H lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N549H confers a gain of function to the Fgfr2 protein as indicated by disengagement of autoinhibitory mechanisms thereby resulting in constitutive activation and downstream pathway activation (PMID: 17525745, PMID: 17803937).
H213Y missense unknown FGFR2 H213Y lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). H213Y has not been biochemically characterized, but is predicted to disrupt the interaction of Fgfr2 with heparan sulfate based on structural modeling (PMID: 19147536).
G462E missense unknown FGFR2 G462E lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). G462E has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
FGFR2 - AFF3 fusion unknown FGFR2-AFF3 results from the fusion of FGFR2 and AFF3 (PMID: 23558953). FGFR2-AFF3 has been identified in breast cancer (PMID: 23558953), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Nov 2018).
S24F missense unknown FGFR2 S24F lies within the extracellular domain of the Fgfr2 protein (UniProt.org). S24F has been identified in sequencing studies (PMID: 19147536), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
Y376C missense gain of function - predicted FGFR2 Y376C (corresponds to Y375C in the canonical isoform) lies within the extracellular domain of the Fgfr2 protein (PMID: 17525745). Y376C is predicted to confer a gain of function to Fgfr2 via constitutive dimerization through inter-molecular disulfide bonds (PMID: 17525745).
P253R missense gain of function FGFR2 P253R lies within the extracellular domain of the Fgfr2 protein (UniProt.org). P253R results in loss of ligand specificity, activation of the p38/MAPK pathway in transgenic mouse models, and is transforming in cell culture (PMID: 11121055, PMID: 20175913, PMID: 23786770).
K659E missense gain of function FGFR2 K659E (also referred to as K660E from the FGFR2IIIb isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K659E leads to increased phosphorylation of downstream signaling molecules and induces colony formation in culture (PMID: 23786770), and in another study, results in the ability to induce senescence and cooperate with Myc to induce transformation of cell lines in culture (PMID: 19403560).
S267_D273dup duplication gain of function FGFR2 S267_D273dup (also referred to as A266_S267insSTVVGGD) indicates the insertion of 7 duplicate amino acids, serine (S)-267 through aspartic acid (D)-273, in the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). S267_D273dup confers a gain of function on Fgfr2 as demonstrated by ligand-independent phosphorylation, dimerization, and oncogenic cell transformation (PMID: 26048680).
K517R missense loss of function FGFR2 K517R lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K517R results in decreased Fgfr2 kinase activity and inhibited cell proliferation in culture (PMID: 19147536).
amp none no effect FGFR2 amp indicates an increased number of copies of the FGFR2 gene. However, the mechanism causing the increase is unspecified.
FGFR2 - OPTN fusion unknown FGFR2-OPTN results from the fusion of FGFR2 and OPTN (PMID: 28034880). FGFR2-OPTN has been identified in intrahepatic cholangiocarcinoma (PMID: 28034880), but has not been biochemically characterized and therefore, the effect on fusion protein function is unknown (PubMed, Nov 2018).
N549K missense gain of function FGFR2 N549K lies within the protein kinase domain of the FGFR2 protein (UniProt.org). N549K confers a gain of function to the Fgfr2 protein, resulting in oncogenic transformation in cell-based studies (PMID: 18552176, PMID: 17803937, PMID: 29533785) and increased MAPK pathway signaling in cultured cells (PMID: 19147536).
L258F missense no effect - predicted FGFR2 L258F lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). L258F has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785) and therefore, is predicted to have no effect on Fgfr2 protein function.
M535T missense unknown FGFR2 M535T lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M535T has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Sep 2018).
N550H missense gain of function FGFR2 N550H (corresponds to N549H in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N550H results in increased Fgfr2 kinase activity, as well as increased Fgfr2 phosphorylation and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
R255Q missense loss of function - predicted FGFR2 R255Q lies within the extracellular domain of the Fgfr2 protein (UniProt.org). R255Q results in decreased activation of Fgfr2 downstream signaling upon Fgf2 stimulation in culture (PMID: 27323706) and therefore, is predicted to result in a loss of Fgfr2 protein function.
A389T missense unknown FGFR2 A389T lies within the helical domain of the Fgfr2 protein (UniProt.org). A389T has not been biochemically characterized, but is not transforming in culture (PMID: 18552176) and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
A315T missense unknown FGFR2 A315T lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). A315T has been identified in the scientific literature (PMID: 17525745), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
E718K missense unknown FGFR2 E718K lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E718K has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
positive unknown unknown FGFR2 positive indicates the presence of the FGFR2 gene, mRNA, and/or protein.
G305R missense unknown FGFR2 G305R lies within the Ig-like C2-type 3 domain of the Fgfr2 protein (UniProt.org). G305R has been identified in sequencing studies (PMID: 19147536, PMID: 28870692), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
E565A missense gain of function FGFR2 E565A lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E565A results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937).
R625Q missense unknown FGFR2 R625Q lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). R625Q has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
FGFR2 - OFD1 fusion unknown FGFR2-OFD1 results from the fusion of FGFR2 and OFD1 (PMID: 23558953). FGFR2-OFD1 has been identified in thyroid carcinoma (PMID: 23558953), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Nov 2018).
D336N missense unknown FGFR2 D336N lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). D336N has been identified in sequencing studies (PMID: 22810696), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
K641R missense gain of function FGFR2 K641R lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K641R results in increased Fgfr2 autophosphorylation and activation of Mek1/2, Stat3 signaling in cell culture (PMID: 23527311).
G227R missense unknown FGFR2 G227R lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniPort.org). G227R has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
D247Y missense unknown FGFR2 D247Y lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). D247Y has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
wild-type none no effect Wild-type FGFR2 indicates that no mutation has been detected within the FGFR2 gene.
V392M missense no effect - predicted FGFR2 V392M lies within the helical domain of the Fgfr2 protein (UniProt.org). V392M has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785).
C342R missense unknown FGFR2 C342R lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). C342R has been identified in sequencing studies (PMID: 28600064, PMID: 25759925), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
M538I missense gain of function FGFR2 M538I lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M538I results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
L770V missense unknown FGFR2 L770V lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L770V has not been biochemically characterized, but is predicted to decrease phospholipase C-gamma activation by Fgfr2 based on structural modeling (PMID: 19147536).
Y340H missense unknown FGFR2 Y340H lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). Y340H has been identified in sequencing studies (PMID: 16418739), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
N550T missense gain of function FGFR2 N550T (corresponds to N549T in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N550T results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
P253L missense unknown FGFR2 P253L lies within the extracellular domain of the Fgfr2 protein (UniProt.org). P253L leads to Apert syndrome (PMID: 26003532), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
Q259* nonsense no effect - predicted FGFR2 Q259* results in a premature truncation of the Fgfr2 protein at amino acid 259 of 821 (UniProt.org). Q259* has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2, in two different cell lines (PMID: 29533785) and therefore, is predicted to have no effect on Fgfr2 protein function.
N550K missense gain of function FGFR2 N550K (corresponds to N549K in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N550K results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
E565G missense gain of function FGFR2 E565G lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E565G results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937).
K310R missense no effect - predicted FGFR2 K310R lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). K310R has not been biochemically characterized, however, is not transforming in cell culture (PMID: 18552176) and therefore, is predicted to have no effect on Fgfr2 protein function.
V564L missense gain of function - predicted FGFR2 V564L lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V564L is predicted to confer a gain of function to the Fgfr2 protein as indicated by increased Fgfr2 kinase activity in cell culture, and has been shown to be associated with secondary resistance to FGFR inhibitors (PMID: 25169980). Y
S252W missense gain of function FGFR2 S252W lies within the extracellular domain of the Fgfr2 protein (UniProt.org). S252W results in loss of ligand specificity, increased Fgfr2 activation, and is transforming in cell culture (PMID: 11121055, PMID: 18552176).
fusion fusion unknown FGFR2 fusion indicates a fusion of the FGFR2 gene, but the fusion partner is unknown.
K660N missense gain of function FGFR2 K660N (corresponds to K559N in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K660N results in increased phosphorylation of Fgfr2 and activation of downstream signaling (PMID: 23527311).
C383R missense gain of function - predicted FGFR2 C383R (also referred to as C382 in the canonical isoform) lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). C383R has not been biochemically characterized, however, C382R results in Fgfr2 autophosphorylation and transformation in culture and therefore, C383R is predicted to confer a gain of function (PMID: 9136983).
S372F missense unknown FGFR2 S372F lies within the extracellular domain of the Fgfr2 protein (PMID: 17525745). S372F has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
FGFR2 - DNM3 fusion gain of function FGFR2-DNM3 results from the fusion of FGFR2 and DNM3, resulting in FGFR2 activation, increased PI3K and MAPK pathway signaling, and increased colony formation in culture (PMID: 29203461). FGFR2-DNM3 has been identified in triple-receptor negative breast cancer (PMID: 29203461).
D304N missense no effect - predicted FGFR2 D304N lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). D304N has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785).
FGFR2 - CIT fusion unknown FGFR2-CIT results from the fusion of FGFR2 and CIT (PMID: 23558953). FGFR2-CIT has been identified in lung adenocarcinoma (PMID: 23558953), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Nov 2018).
R203H missense unknown FGFR2 R203H lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). R203H has been identified in sequencing studies (PMID: 22810696), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
Q212K missense unknown FGFR2 Q212K lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). Q212K has been identified in sequencing studies (PMID: 23917401), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
K641N missense gain of function FGFR2 K641N lies within the protein kinase domain of the Fgfr2b protein (UniProt.org). K641N (reported as K642N) results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
I547D missense unknown FGFR2 I547D lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). I547D has been identified in sequencing studies (PMID: 22383975), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
N550S missense gain of function FGFR2 N550S lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N550S results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
C342Y missense gain of function FGFR2 C342Y lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). C342Y results in activation of Fgfr2 signaling as indicated by decreased differentiation and increased apoptosis in osteoblasts in culture and in transgenic animal models (PMID: 10851026, PMID: 15316116).
K292M missense no effect - predicted FGFR2 K292M lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). K292M has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785) and therefore, is predicted to have no effect on Fgfr2 protein function.
FGFR2 - GAB2 fusion unknown FGFR2-GAB2 results from the fusion of FGFR2 and GAB2 (PMID: 28978721). FGFR2-GAB2 has been identified in breast cancer (PMID: 28978721), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Nov 2018).
L617F missense gain of function - predicted FGFR2 L617F lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L617F results in enhanced Fgfr2 autophosphorylation and activation of Runx2, but activation of Mapk/Erk was similar to wild-type Fgfr2 in cell culture (PMID: 23913723) and therefore, is predicted to result in a loss of Fgfr2 protein function.
R210Q missense unknown FGFR2 R210Q lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). R210Q has been identified in sequencing studies (PMID: 26343386), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
S688F missense unknown FGFR2 S688F lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). S688F has been identified in the scientific literature (PMID: 19147536), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
K660E missense gain of function FGFR2 K660E (corresponds to K659E in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K660E results in increased phosphorylation of Fgfr2, activation of downstream signaling, and is transforming in cell culture (PMID: 23786770).
FGFR2 - FAM76A fusion gain of function - predicted FGFR2-FAM76A results from the fusion of FGFR2 and FAM76A, which leads to increased proliferation and transformation in cell culture (PMID: 24563622) and therefore, is predicted to result in a gain of protein function.
G227E missense unknown FGFR2 G227E lies within the Ig-like C2-type 2 domain of the FGFR2 protein (UniProt.org). G227E results in impaired receptor processing and trafficking to the cell membrane and reduced ligand-dependent cell proliferation in one study (PMID: 19147536), but results in similar cell proliferation and viability levels as wild-type Fgfr2 in two different cell lines in another study (PMID: 29533785), and therefore, its effect on the Fgfr2 protein function is unknown.
R625T missense unknown FGFR2 R625T lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). R625T has been identified in sequencing studies (PMID: 17344846), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
F276V missense unknown FGFR2 F276V lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). F276V has been identified in sequencing studies (PMID: 24578066), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
I380V missense unknown FGFR2 I380V lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). I380V has been identified in sequencing studies (PMID: 18948947), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
G690R missense unknown FGFR2 G690R lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). G690R has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
L617V missense unknown FGFR2 L617V lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L617V has been demonstrated to confer resistance to Fgfr inhibitors in cell culture (PMID: 28034880), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Jun 2018). Y
M186T missense no effect - predicted FGFR2 M186T lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). M186T has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785) and therefore, is predicted to have no effect on Fgfr2 protein function.
P708S missense unknown FGFR2 P708S lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). P708S has been identified in the scientific literature (PMID: 19147536, PMID: 28481359), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
G272V missense unknown FGFR2 G272V lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). G272V has been identified in the scientific literature (PMID: 20106510), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
P775L missense unknown FGFR2 P775L lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). P775L has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
M391R missense unknown FGFR2 M391R lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). M391R results in increased nucleolar Fgfr2 activity and cell proliferation in one study (PMID: 24908667), but results in similar cell proliferation and viability levels as wild-type Fgfr2 in two different cell lines in another study (PMID: 29533785) and therefore, its effect on the Fgfr2 protein function is unknown.
F386_A389del missense no effect - predicted FGFR2 F386_A389del results in the deletion of four amino acids in the Fgfr2 protein from amino acids 386 to 389 (UniProt.org). F386_A389del has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785).
G583R missense unknown FGFR2 G583R lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). G583R has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
I547V missense unknown FGFR2 I547V lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). I547V has been identified in sequencing studies (PMID: 17525745), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
L761Tfs*55 frameshift unknown FGFR2 L761Tfs*55 indicates a shift in the reading frame starting at amino acid 761 and terminating 55 residues downstream causing a premature truncation of the 821 amino acid Fgfr2 protein (UniProt.org). L761Tfs*55 results in increased transformation ability in one of two different cell lines (PMID: 29533785) and therefore, its effect on Fgfr2 protein function is unknown.
S372C missense gain of function - predicted FGFR2 S372C lies within the extracellular domain of the Fgfr2 protein (PMID: 17525745). S372C (reported as S373C) is predicted to confer a gain of function to the Fgfr2 protein, resulting in constitutive dimerization of the receptor (PMID: 17525745).
V564I missense gain of function - predicted FGFR2 V564I lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V564I is predicted to confer a gain of function to the Fgfr2 protein as indicated by increased Fgfr2 kinase activity in cell culture, and has been shown to be associated with secondary resistance to FGFR inhibitors (PMID: 25169980). Y
H544Q missense unknown FGFR2 H544Q lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). H544Q has been identified in sequencing studies (PMID: 18948947), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
D479N missense unknown FGFR2 D479N lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). D479N has been identified in sequencing studies (PMID: 25035393) but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
R678G missense gain of function FGFR2 R678G lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). R678G results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937).
T764fs frameshift unknown FGFR2 T764fs results in a change in the amino acid sequence of the Fgfr2 protein beginning at aa 764 of 821, likely resulting in premature truncation of the functional protein (UniProt.org). T764fs has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
S252F missense unknown FGFR2 S252F lies within the extracellular domain of the Fgfr2 protein (UniProt.org). S252F has been identified in sequencing studies (PMID: 16418739), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
E566A missense gain of function - predicted FGFR2 E566A (corresponds to E565A in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E566A has not been biochemically characterized, but is predicted to result in increased Fgfr2 kinase activity due to decreased Fgfr2 autoinhibition (PMID: 23908597).
rearrange unknown unknown FGFR2 rearrangement indicates an unspecified rearrangement of the FGFR2 gene.
L551I missense unknown FGFR2 L551I lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L551I has been identified in sequencing studies (PMID: 22810696), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
N549D missense unknown FGFR2 N549D lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). N549D has been demonstrated to confer resistance to Fgfr inhibitors in cell culture (PMID: 28034880), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Jun 2018). Y
G338R missense unknown FGFR2 G338R lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). G338R has been identified in sequencing studies (PMID: 16418739), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
S436F missense no effect - predicted FGFR2 S436F lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). S436F has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785) and therefore, is predicted to have no effect on Fgfr2 protein function.
FGFR2 - COL14A1 fusion unknown FGFR2-COL14A1 results from the fusion of FGFR2 and COL14A1 (PMID: 25485619). FGFR2-COL14A1 has been identified in lung cancer (PMID: 25485619), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Jul 2018).
Y375C missense gain of function FGFR2 Y375C lies within the extracellular juxtamembrane domain of the Fgfr2 protein (PMID: 17525745). Y375C results in constitutive phosphorylation of Fgfr2 in cell culture, activation of Mapk p38 signaling, and abnormal proliferation and differentiation in the skin and skull of transgenic mouse models (PMID: 22585574).
E219K missense unknown FGFR2 E219K lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). E219K has not been biochemically characterized, but is predicted to disrupt Fgf- and heparin-induced Fgfr2 dimerization based on structural modeling (PMID: 19147536).
S252L missense unknown FGFR2 S252L lies within the extracellular domain of the Fgfr2 protein (UniProt.org). S252L has been identified in sequencing studies (PMID: 25669975, PMID: 24952746), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
R251* nonsense loss of function - predicted FGFR2 R251* results in a premature truncation of the Fgfr2 protein at amino acid 251 of 821 (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), R251* is predicted to lead to a loss of Fgfr2 function.
E470Q missense unknown FGFR2 E470Q lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). E470Q has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
G701S missense unknown FGFR2 G701S lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). G701S has not been characterized however, is predicted to inhibit Fgfr2 kinase activity indirectly by structural modeling (PMID: 19147536).
T394A missense no effect - predicted FGFR2 T394A lies within the helical domain of the Fgfr2 protein (UniProt.org). T394A has not been biochemically characterized, but results in similar cell proliferation and viability levels as wild-type Fgfr2 (PMID: 29533785) and is predicted to have no effect on Fgfr2 protein function.
V248D missense unknown FGFR2 V248D lies within the extracellular domain of the Fgfr2 protein (UniProt.org). V248D has not been biochemically characterized, but is predicted to to destabilize the tertiary fold of the Fgfr2 protein based on structural modeling (PMID: 19147536).
L397M missense unknown FGFR2 L397M lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). L397M has been identified in sequencing studies (PMID: 22383975), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
I642V missense loss of function FGFR2 I642V lies within the protein kinase domain of the FGFR2 protein (PMID: 19147536). I642V confers a loss of function to the FGFR2 protein resulting in a loss of protein kinase activity and reduced downstream MAPK signaling pathway activation (PMID: 19147536).
E777K missense unknown FGFR2 E777K lies within the cytoplasmic domain of the Fgfr2 protein (UniPort.org). E777K has been identified in sequencing studies (PMID: 29107334), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
E574K missense unknown FGFR2 E574K lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E574K has been identified in the scientific literature (PMID: 19147536), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
R759Q missense unknown FGFR2 R759Q lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). R759Q has not been biochemically characterized, but is predicted to disrupt Fgfr2 kinase activity based on structural modeling (PMID: 19147536).
P256S missense unknown FGFR2 P256S lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). P256S has been identified in sequencing studies (PMID: 25669975), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
K659N missense gain of function FGFR2 K659N (also referred to as K660N from the FGFR2IIIb isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K659N confers a gain of function to the Fgfr2 protein as demonstrated by increased autophosphorylation and phosphorylation of downstream targets, Mek and Stat3 (PMID: 23527311).
A344G missense unknown FGFR2 A344G lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). A344G has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
FGFR2 - KIAA1598 fusion unknown FGFR2-SHTN1(also referred to as FGFR2-KIAA1598) results from the fusion of FGFR2 and SHTN1(PMID: 25536104). FGFR2-SHTN1 has been identified in cholangiocarinoma (PMID: 25536104), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Nov 2018).
FGFR2 - AHCYL1 fusion gain of function FGFR2-AHCYL1 results from the fusion of FGFR1 and AHCYL1, resulting in the ability to activate MAPK signaling and induce transformation of cells in culture and in animal models (PMID: 24122810).
V392A missense unknown FGFR2 V392A lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). V392A has been identified in sequencing studies (PMID: 23619168, PMID: 21798897), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
I548V missense gain of function FGFR2 I548V lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). I548V results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
P253S missense unknown FGFR2 P253S lies within the extracellular domain of the Fgfr2 protein (UniProt.org). P253S has been identified in sequencing studies (PMID: 11781872), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
M640I missense unknown FGFR2 M640I lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M640I has been identified in sequencing studies (PMID: 19147536, PMID: 26343386), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
R664W missense loss of function - predicted FGFR2 R664W lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). R664W results in a 60% decrease in autophosphorylation compared to wild-type in an in vitro kinase assay (PMID: 28151998) and therefore, is predicted to result in loss of Fgfr2 protein function.
K405E missense unknown FGFR2 K405E lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). K405E has been identified in sequencing studies (PMID: 25669975), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
FGFR2 - TNS1 fusion unknown FGFR2-TNS1 results from the fusion of FGFR2 and TNS1 (PMID: 29203461). FGFR2-TNS1 has been identified in triple-receptor negative breast cancer (PMID: 29203461), but has not been biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Nov 2018).
A314D missense unknown FGFR2 A314D lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). A314D has been identified in sequencing studies (PMID: 18552176), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
G583W missense unknown FGFR2 G583W lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). G583W has been identified in sequencing studies (PMID: 22960745, PMID: 24836576), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
K420I missense unknown FGFR2 K420I lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org).K420I has been identified in sequencing studies (PMID: 25035393), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
V395D missense unknown FGFR2 V395D lies within the transmembrane domain of the Fgfr2 protein (UniProt.org). V395D has been identified in sequencing studies (PMID: 22383975), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
V565I missense gain of function FGFR2 V565I (corresponds to V564I in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V565I results in increased Fgfr2 kinase activity and enhanced cell proliferation in the presence of ligand in culture (PMID: 23908597).
W290* nonsense loss of function - predicted FGFR2 W290* results in a premature truncation of the Fgfr2 protein at aa 290 of 821 (UniProt.org). Due to a loss of the protein kinase domain (UniProt.org), W290* is predicted to lead to a loss of function.
A648T missense loss of function FGFR2 A648T lies within the protein kinase domain of the FGFR2 protein (PMID: 19147536). A648T confers a loss of function to the Fgfr2 protein resulting in a loss of protein kinase activity and reduced downstream MAPK signaling pathway activation (PMID: 19147536).
N211I missense unknown FGFR2 N211I lies within the Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). N211I has been identified in sequencing studies (PMID: 18552176), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
P582L missense unknown FGFR2 P582L lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). P582L has been identified in sequencing studies (PMID: 27425854, PMID: 24755471, PMID: 23856246), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
S587C missense unknown FGFR2 S587C lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). S587C has been identified in the scientific literature (PMID: 23000897), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
E475K missense unknown FGFR2 E475K lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). E475K demonstrated slightly increased Fgfr2 kinase activity, but also decreased protein stability and cell proliferation in culture (PMID: 19147536) and therefore, its effect on the Fgfr2 protein function is unknown.
FGFR2 - MGEA5 fusion unknown FGFR2-MGEA5 results from the fusion of FGFR2 and MGEA5 (PMID: 24550739). FGFR2-MGEA5 has been identified in intrahepatic cholangiocarcinoma and is associated with increased Fgfr2 expression and phosphorylation of Frs2 and Erk in patient tissue (PMID: 24550739), but has not been fully biochemically characterized and therefore, the effect on protein function is unknown (PubMed, Nov 2018).
K525E missense gain of function FGFR2 K525E (corresponds to K641E in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K525E results in increased Fgfr2 autophosphorylation and substrate phosphorylation in in vitro kinase assays (PMID: 17803937).
C382R missense gain of function FGFR2 C382R (also referred to as C383R) lies within the helical domain of the Fgfr2 protein (UniProt.org). C382R confers a gain of function to the Fgfr2 protein resulting in constitutive MAPK pathway activation, and is transforming in cultured cells (PMID: 24993163).
V755I missense no effect FGFR2 V755I (corresponds to V754I in the canonical isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V755I has activity similar to wild-type Fgfr2 as demonstrated by equivalent substrate phosphorylation and the lack of oncogenic cell transformation (PMID: 26048680).
FGFR2 - TACC3 fusion gain of function FGFR2-TACC3 results from the fusion of FGFR2 and TACC3, resulting in an oncogenic protein as demonstrated by ligand-independent phosphorylation, dimerization, and oncogenic transformation (PMID: 26048680).
T341P missense gain of function FGFR2 T341P lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). T341P results in increased phosphorylation of Fgfr2 and is transforming in cell culture (PMID: 9539778).
V564F missense gain of function - predicted FGFR2 V564F lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). V564F is predicted to confer a gain of function as demonstrated by increased Fgfr2 kinase activity in cell culture (PMID: 25169980), and has been shown to be associated with secondary resistance to FGFR inhibitors (PMID: 28034880). Y
T786K missense unknown FGFR2 T786K lies within the cytoplasmic domain of the Fgfr2 protein (UniProt.org). T786K has been identified in sequencing studies (PMID: 22960745), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
FGFR2 - CCDC6 fusion gain of function FGFR2-CCDC6 results from the fusion of FGFR2 and CCDC6, resulting in the ability to induce oligomerization, activate Fgfr kinase activity, and induce cell proliferation (PMID: 23558953).
FGFR2 - BICC1 fusion gain of function FGFR2-BICC1 results from the fusion of FGFR2 and BICC1, resulting in the ability to induce oligomerization, Fgfr kinase activity, Mapk signaling and transformation of cells in culture and in animal models (PMID: 23558953, PMID: 24122810).
C342S missense unknown FGFR2 C342S lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). C342S has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
A344P missense unknown FGFR2 A344P lies within the Ig-like C2-type domain 3 of the Fgfr2 protein (UniProt.org). A344P has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
Y769* nonsense unknown FGFR2 Y769* results in a premature truncation of the Fgfr2 protein at amino acid 769 of 821 (UniProt.org). Y769* has not been characterized in the scientific literature and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2018).
Molecular Profile Protein Effect Treatment Approaches
FGFR2 D530N loss of function
FGFR2 R330W unknown
FGFR2 A264T unknown
FGFR2 V564T no effect - predicted
FGFR2 - ZMYM4 unknown
FGFR2 E565A FGFR2 K659M FGFR2 N549H FGFR2 N549K FGFR2 V564F FGFR2-ZMYM4
FGFR2 G583V unknown
FGFR2 Q620K unknown
FGFR2 D138N unknown
FGFR2 T370R unknown
FGFR2 D283N unknown
FGFR2 I590M unknown
FGFR2 Y281C unknown
FGFR2 act mut gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K659M unknown
FGFR2 E731K unknown
FGFR2 M537I unknown
FGFR2 L772F unknown
FGFR2 M536I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 W290C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 I642T unknown
FGFR2 C278F unknown
FGFR2 Y588D unknown
FGFR2 R165W unknown
FGFR2 G302W unknown
FGFR2 R251Q loss of function
FGFR2 F276C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 M584V unknown
FGFR2 S57L unknown
FGFR2 - PPHLN1 gain of function
FGFR2 E566G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 - KIAA1967 unknown
FGFR2-CASP7 unknown
FGFR2 A97T unknown
FGFR2 E116K unknown
FGFR2 D602E unknown
FGFR2 dec exp KRAS mut
FGFR2 dec exp no effect
FGFR2 amp FGFR2 over exp
FGFR2 over exp no effect FGFR Inhibitor (Pan) FGFR2 Inhibitor GSK3052230
FGFR2 S354C unknown
FGFR2 S799A no effect - predicted
FGFR2 E636* loss of function - predicted
FGFR2 D101Y gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S347C unknown
FGFR2 T730S no effect
FGFR2 R203C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E596K unknown
FGFR2 C342F unknown
FGFR2 E636K unknown
FGFR2 E160A unknown
FGFR2 S267P unknown
FGFR2 Y340C unknown
FGFR2 Q289P unknown
FGFR2 P303L unknown
FGFR2 K526E gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 L618M gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E695K unknown
FGFR2 mutant unknown
FGFR2 R6P unknown
FGFR2 M538R unknown
FGFR2 W290_I291delinsC gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 A315S unknown
FGFR2 G183fs loss of function - predicted
FGFR2 G384E unknown
FGFR2 N549T gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C382Y no effect - predicted
FGFR2 G663E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V77M unknown
FGFR2 G271E loss of function
FGFR2 V564M unknown
FGFR2 inact mut loss of function
FGR2 E565A FGFR2 K641R FGFR2 L617V FGFR2 N549H FGFR2 V564F FGFR2-OPTN
FGFR2 N549H gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 H213Y unknown
FGFR2 G462E unknown
FGFR2-AFF3 unknown
FGFR2 S24F unknown
FGFR2 Y376C gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 P253R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K659E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S267_D273dup gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K517R loss of function
FGFR2 amp no effect FGFR Inhibitor (Pan) FGFR2 Antibody FGFR2 Inhibitor
FGFR1 amp FGFR2 amp
FGFR2 amp FGFR2-GAB2
ERBB2 amp FGFR2 amp
FGFR2 amp FGFR2 rearrange
FGFR2 amp FGFR2-COL14A1
FGFR2 amp FGFR2 fusion
FGFR2 - OPTN unknown
FGFR2 K310R FGFR2 N549K
FGFR2 N549K gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 L258F no effect - predicted
FGFR2 M535T unknown
FGFR2 N550H gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 R255Q loss of function - predicted
FGFR2 A389T unknown
FGFR2 A315T unknown
FGFR2 E718K unknown
FGFR2 positive unknown
FGFR2 pos FGFR3 pos
FGFR1 pos FGFR2 pos
FGFR2 G305R unknown
FGFR2 E565A gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 R625Q unknown
FGFR2-OFD1 unknown
FGFR2 D336N unknown
FGFR2 K641R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 G227R unknown
FGFR2 D247Y unknown
FGFR2 wild-type ERBB2 amp
FGFR2 wild-type no effect
FGFR2 V392M no effect - predicted
FGFR2 C342R unknown
FGFR2 M538I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 L770V unknown
FGFR2 Y340H unknown
FGFR2 N550T gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 P253L unknown
FGFR2 Q259* no effect - predicted
FGFR2 K310R FGFR2 N550K
FGFR2 N550K gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C383R FGFR2 N550K
FGFR2 C382R FGFR2 N550K
FGFR2 E565G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K310R no effect - predicted
FGFR2 V564L gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S252W gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor GSK3052230
FGFR2 fusion FGFR2 V564F
FGFR2 fusion FGFR3 - TACC3
FGFR2 fusion unknown
FGFR2 K660N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C383R gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S372F unknown
BRCA1 loss FGFR2-DNM3
FGFR2-DNM3 gain of function
FGFR2 D304N no effect - predicted
FGFR2 - CIT unknown
FGFR2 R203H unknown
FGFR2 Q212K unknown
FGFR2 K641N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 I547D unknown
FGFR2 N550S gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C342Y gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 K292M no effect - predicted
FGFR2-GAB2 unknown
FGFR2 L617F gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 R210Q unknown
FGFR2 S688F unknown
FGFR2 K660E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2-FAM76A gain of function - predicted
FGFR2 G227E unknown
FGFR2 R625T unknown
FGFR2 F276V unknown
FGFR2 I380V unknown
FGFR2 G690R unknown
FGFR2 L617V unknown
FGFR2 M186T no effect - predicted
FGFR2 P708S unknown
FGFR2 G272V unknown
FGFR2 P775L unknown
FGFR2 M391R unknown
FGFR2 F386_A389del no effect - predicted
FGFR2 G583R unknown
FGFR2 I547V unknown
FGFR2 L761Tfs*55 unknown FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 S372C gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V564I gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 H544Q unknown
FGFR2 D479N unknown
FGFR2 R678G gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 T764fs unknown
FGFR2 S252F unknown
FGFR2 E566A gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 rearrange unknown
FGFR2 L551I unknown
FGFR2 N549D unknown
FGFR2 G338R unknown
FGFR2 S436F no effect - predicted
FGFR2-COL14A1 unknown
FGFR2 Y375C gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 E219K unknown
FGFR2 S252L unknown
FGFR2 R251* loss of function - predicted
FGFR2 E470Q unknown
FGFR2 G701S unknown
FGFR2 T394A no effect - predicted
FGFR2 V248D unknown
FGFR2 L397M unknown
FGFR2 I642V loss of function
FGFR2 E777K unknown
FGFR2 E574K unknown
FGFR2 R759Q unknown
FGFR2 P256S unknown
FGFR2 K659N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 A344G unknown
FGFR2-KIAA1598 unknown
FGFR2-AHCYL1 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V392A unknown
FGFR2 I548V gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 P253S unknown
FGFR2 M640I unknown
FGFR2 R664W loss of function - predicted
FGFR2 K405E unknown
FGFR2-TNS1 unknown
FGFR2 A314D unknown
FGFR2 G583W unknown
FGFR2 K420I unknown
FGFR2 V395D unknown
FGFR2 V565I gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 W290* loss of function - predicted
FGFR2 A648T loss of function
FGFR2 N211I unknown
FGFR2 P582L unknown
FGFR2 S587C unknown
FGFR2 E475K unknown
FGFR2 - MGEA5 unknown
FGFR2 K525E gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C382R gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V755I no effect
FGFR2 - TACC3 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 T341P gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 V564F FGFR2-BICC1
FGFR2 V564F gain of function - predicted FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 T786K unknown
FGFR2-CCDC6 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2-BICC1 gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor
FGFR2 C342S unknown
FGFR2 A344P unknown
FGFR2 Y769* unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 E565A FGFR2 K659M FGFR2 N549H FGFR2 N549K FGFR2 V564F FGFR2-ZMYM4 cholangiocarcinoma predicted - resistant BGJ398 Clinical Study Actionable In a clinical study, FGFR2 mutations E565A, K659M, N549H, N549K and V564F were identified in the cell-free DNA of a cholangiocarcinoma patient harboring FGFR2-ZMYM4 fusion after the patient progressed while on BGJ398 treatment (PMID: 28034880). 28034880
FGFR2 act mut stomach carcinoma sensitive S-49076 Preclinical - Cell line xenograft Actionable In a preclinical study, S-49076 inhibited Met activation, resulting in growth inhibition of gastric carcinoma cells harboring FGFR2 activating mutations in culture and in cell line xenograft models (PMID: 23804704). 23804704
FGFR2 act mut Advanced Solid Tumor decreased response Cediranib Preclinical Actionable In a preclinical study, transformed cells expressing constitutively active FGFR2 demonstrated reduced sensitivity to inhibition of receptor phosphorylation and cell proliferation by Cediranib (AZD-2171) in culture, when compared to other tyrosine kinase inhibitors (PMID: 22238366). 22238366
FGFR2 act mut Advanced Solid Tumor sensitive Dovitinib Preclinical Actionable In a preclinical study, Dovitinib (TKI258) inhibited receptor phosphorylation and cell proliferation in transformed cells expressing constitutively active FGFR2 in culture (PMID: 22238366). 22238366
FGFR2 act mut Advanced Solid Tumor sensitive Debio 1347 Phase I Actionable In a Phase I trial, Debio 1347 (CH5183284) dosing regimen has been determined in solid tumor patients with activating FGFR2 alterations (JCO, Vol 33, No 15_suppl (May 20 Supplement), 2015: 2540). detail...
FGFR2 act mut Advanced Solid Tumor decreased response Nintedanib Preclinical Actionable In a preclinical study, transformed cells expressing constitutively active FGFR2 demonstrated reduced sensitivity to Ofev (Nintedanib) in culture, when compared to other tyrosine kinase inhibitors (PMID: 22238366). 22238366
FGFR2 act mut Advanced Solid Tumor sensitive Erdafitinib Phase I Actionable In a Phase I trial, Erdafitinib (JNJ-42756493) treatment resulted in stable disease in 70% (16/23) and partial response in 22% (5/23) of patients with advanced solid tumors harboring FGFR 1-4 activating mutations (including amplifications, mutations and translocations), while no antitumor activity was observed in patients with unknown or no known changes in FGFR (PMID: 26324363). 26324363
FGFR2 act mut Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited receptor phosphorylation and cell growth in transformed cells expressing constitutively active FGFR2 in culture (PMID: 22238366). 22238366
FGFR2 act mut Advanced Solid Tumor decreased response Brivanib Preclinical Actionable In a preclinical study, transformed cells expressing constitutively active FGFR2 demonstrated reduced sensitivity to inhibition of receptor phosphorylation and cell proliferation by Brivanib (BMS-540215) in culture, when compared to other tyrosine kinase inhibitors (PMID: 22238366). 22238366
FGFR2 act mut endometrial cancer sensitive Dovitinib Preclinical - Cell line xenograft Actionable In a preclinical study, both cell lines and cell line xenograft models of endometrial cancer with FGFR2 activating mutations showed greater sensitivity to Dovitinib (TKI258) as compared to FGFR2 wild-type (PMID: 23443805). 23443805
FGFR2 M536I Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited Fgfr2 phosphorylation and proliferation in transformed cells expressing FGFR2 M536I (PMID: 23908597). 23908597
FGFR2 M536I Advanced Solid Tumor decreased response PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 M536I demonstrated a decreased response to treatment with PD173074 (PMID: 23908597). 23908597
FGFR2 M536I Advanced Solid Tumor decreased response Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 M536I demonstrated a decreased response to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 W290C Advanced Solid Tumor sensitive BGJ398 Preclinical - Cell line xenograft Actionable In a preclinical study, BGJ398 inhibited growth of transformed cells expressing FGFR2 W290C in culture and inhibited tumor growth in xenograft models (PMID: 23786770). 23786770
FGFR2 W290C Advanced Solid Tumor sensitive Pazopanib Preclinical - Cell culture Actionable In a preclinical study, Votrient (pazopanib) inhibited growth of transformed cells expressing FGFR2 W290C in culture (PMID: 23786770). 23786770
FGFR2 W290C Advanced Solid Tumor sensitive Cediranib Preclinical - Cell culture Actionable In a preclinical study, Cediranib (AZD-2171) inhibited growth of transformed cells expressing FGFR2 W290C in culture (PMID: 23786770). 23786770
FGFR2 W290C Advanced Solid Tumor sensitive AZD4547 Preclinical - Cell culture Actionable In a preclinical study, AZD4547 inhibited growth of transformed cells expressing FGFR2 W290C in culture (PMID: 23786770). 23786770
FGFR2 W290C Advanced Solid Tumor sensitive Lenvatinib Preclinical - Cell culture Actionable In a preclinical study, Lenvima (lenvatinib) inhibited growth of transformed cells expressing FGFR2 W290C in culture (PMID: 23786770). 23786770
FGFR2 W290C Advanced Solid Tumor sensitive Ponatinib Preclinical - Cell culture Actionable In a preclinical study, Iclusig (ponatinib) inhibited growth of transformed cells expressing FGFR2 W290C in culture (PMID: 23786770). 23786770
FGFR2 F276C intrahepatic cholangiocarcinoma predicted - sensitive BGJ398 Phase I Actionable In a Phase II trial, BGJ398 treatment resulted in partial response after 2 month of therapy and maintained the response for 4 months in a patient with advanced intrahepatic cholangiocarcinoma harboring a FGFR2 F276C mutation, which is consistent with inhibition of Erk signaling in cholangiocarcinoma cells expressing FGFR2 F274C in culture (JCO Precis Oncol 2017:1, 1-13; NCT02150967). detail...
FGFR2 E566G Advanced Solid Tumor resistant PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 E566G were resistant to treatment with PD173074 (PMID: 23908597). 23908597
FGFR2 E566G Advanced Solid Tumor resistant Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 E566G were resistant to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 E566G Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited Fgfr2 phosphorylation and proliferation in transformed cells expressing FGFR2 E566G (PMID: 23908597). 23908597
FGFR2-CASP7 Advanced Solid Tumor sensitive Derazantinib Preclinical - Cell culture Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited growth of transformed cells expressing FGFR2-CASP7 in culture (PMID: 27627808). 27627808
FGFR2 dec exp KRAS mut lung cancer no benefit Trametinib Preclinical Actionable In a preclinical study, knocking down of Fgfr2 through shRNA did not sensitize KRAS mutant lung cancer cells to Mekinist (trametinib) induced growth inhibition in culture (PMID: 27338794). 27338794
FGFR2 dec exp breast cancer resistant BAY1187982 Preclinical - Cell culture Actionable In a preclinical study, BAY1187982 did not inhibit growth of breast cancer cells with very low Fgfr2 expression level in culture (PMID: 27543601). 27543601
FGFR2 amp FGFR2 over exp stomach cancer sensitive BGJ398 Preclinical - Pdx Actionable In a preclinical study, BGJ398 decreased Myc expression and inhibited tumor growth in patient-derived xenograft (PDX) models of gastric cancer with FGFR2 amplification and over expression (PMID: 27401245). 27401245
FGFR2 amp FGFR2 over exp stomach cancer sensitive AZD4547 Preclinical - Pdx Actionable In a preclinical study, AZD4547 decreased Myc expression and inhibited tumor growth in patient-derived xenograft (PDX) models of gastric cancer with FGFR2 amplification and over expression (PMID: 27401245). 27401245
FGFR2 over exp endometrial cancer resistant AZD4547 Preclinical - Cell culture Actionable In a preclinical study, endometrial cells with Fgfr2 overexpression were resistant to the anti-proliferative effects of AZD4547 (PMID: 26294741). 26294741
FGFR2 over exp Advanced Solid Tumor sensitive PRN1371 Preclinical - Cell culture Actionable In a preclinical study, PRN1371 inhibited proliferation of transformed cells over expressing wild-type FGFR2 in culture (PMID: 28978721). 28978721
FGFR2 over exp Advanced Solid Tumor sensitive Derazantinib Preclinical - Cell line xenograft Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited growth of transformed cells overexpressing Fgfr2 in culture and in cell line xenograft models (PMID: 27627808). 27627808
FGFR2 over exp breast cancer sensitive PD173074 Preclinical Actionable In a preclinical study, PD173074 inhibited proliferation of breast cancer cells over expressing FGFR2 in culture (PMID: 22869148). 22869148
FGFR2 over exp breast cancer sensitive AZD4547 Preclinical Actionable In a preclinical study, AZD4547 inhibited downstream Erk phosphorylation and proliferation of breast cancer cells over expressing FGFR2 in culture (PMID: 22869148). 22869148
FGFR2 over exp breast cancer sensitive AZ8010 Preclinical Actionable In a preclinical study, AZ8010 inhibited downstream Erk phosphorylation and proliferation of breast cancer cells over expressing FGFR2 in culture (PMID: 22869148). 22869148
FGFR2 over exp colorectal cancer sensitive BAY1187982 Preclinical - Cell line xenograft Actionable In a preclinical study, BAY1187982 inhibited survival of colorectal cancer cells with over expressing Fgfr2 in culture, and suppressed tumor growth in cell line xenograft models (PMID: 27543601). 27543601
FGFR2 L618M Advanced Solid Tumor decreased response PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 L618M demonstrated a decreased response to treatment with PD173074 (PMID: 23908597). 23908597
FGFR2 L618M Advanced Solid Tumor decreased response Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 L618M demonstrated a decreased response to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 L618M Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 L618M were sensitive to treatment with Iclusig (ponatinib) (PMID: 23908597). 23908597
FGFR2 mutant cholangiocarcinoma sensitive BGJ398 Phase I Actionable In a Phase I trial, a patient with cholangiocarcinoma harboring an FGFR2 mutation demonstrated a decreased tumor burden when treated with BGJ398 (PMID: 27870574). 27870574
FGFR2 mutant endometrial cancer sensitive PRN1371 Preclinical - Cell culture Actionable In a preclinical study, PRN1371 inhibited proliferation of endometrial cancer cells harboring FGFR2 mutations in culture (AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1249). detail...
FGFR2 mutant endometrial cancer sensitive BGJ398 Preclinical Actionable In a preclinical study, BGJ398 inhibited the growth of FGFR2-mutated endometrial cancer cells in vitro and in xenograft models (PMID: 23443805). 23443805
FGFR2 mutant Advanced Solid Tumor sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, a variety of cancer cell lines harboring mutations in FGFR1, FGFR2, and/or FGFR3 demonstrated sensitivity to INCB054828 in culture and in cell line xenograft models, resulting in inhibition of tumor growth (Cancer Res 2015;75(15 Suppl):Abstract nr 771). detail...
FGFR2 mutant Advanced Solid Tumor predicted - sensitive AZD4547 Phase II Actionable In a Phase II (MATCH) trial, AZD4547 treatment resulted in stable disease in 40% (6/16) of patients with advanced solid tumors harboring FGFR single nucleotide variants, with a 6-month progression-free survival rate of 8% (J Clin Oncol 36, 2018 (suppl; abstr 2503); NCT02465060). detail...
FGFR2 mutant transitional cell carcinoma predicted - sensitive Erdafitinib Phase II Actionable In a Phase II trial, Erdafitinib (JNJ-42756493) treatment resulted in an objective response rate of 42% (40/96, 3 complete response, 37 partial response) and a disease control rate of 80% in patients with metastatic or unresectable urothelial carcinoma harboring FGFR alterations (J Clin Oncol 36, 2018 (suppl; abstr 4503); NCT02365597). detail...
FGFR2 W290_I291delinsC Advanced Solid Tumor sensitive BGJ398 Preclinical Actionable In a preclinical study, BGJ398 prevented oncogenic transformation of cells expressing FGFR2 W290_I291delinsC (PMID: 26048680). 26048680
FGFR2 W290_I291delinsC Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited downstream phosphorylation of Akt and Erk1/2 in cells expressing Fgfr2 W290_I291delinsC (PMID: 26048680). 26048680
FGR2 E565A FGFR2 K641R FGFR2 L617V FGFR2 N549H FGFR2 V564F FGFR2-OPTN cholangiocarcinoma predicted - resistant BGJ398 Clinical Study Actionable In a clinical study, FGFR2 mutations E565A, K641R, L617V, N549H and V564F were identified in the cell-free DNA of a cholangiocarcinoma patient harboring FGFR2-OPTN fusion after the patient progressed while on BGJ398 treatment (PMID: 28034880). 28034880
FGFR2 P253R head and neck squamous cell carcinoma predicted - sensitive Pazopanib Clinical Study Actionable In a case study, treatment with Votrient (pazopanib) resulted in reduced tumor size in a patient with head and neck squamous cell carcinoma harboring FGFR2 P253R (PMID: 23786770). 23786770
FGFR2 S267_D273dup Advanced Solid Tumor sensitive BGJ398 Preclinical Actionable In a preclinical study, BGJ398 prevented oncogenic transformation of cells expressing FGFR2 S267_D273dup (PMID: 26048680). 26048680
FGFR2 S267_D273dup Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited downstream phosphorylation of Akt and Erk1/2 in cells expressing Fgfr2 S267_D273dup (PMID: 26048680). 26048680
FGFR2 amp Her2-receptor positive breast cancer sensitive Dovitinib Phase I Actionable In a Phase I trial, Dovitinib (TKI258) displayed safety and preliminary efficacy resulting in tumor regression of 28.2% and 18.5% in two patients with FGFR2 amplified Erbb2 (Her2)-receptor positive breast cancer (PMID: 23658459). 23658459
FGFR2 amp stomach cancer predicted - sensitive PRN1109 Preclinical - Cell line xenograft Actionable In a preclinical study, PRN1109 treatment resulted in tumor regression in gastric cancer cell line xenograft models harboring FGFR2 amplification (Eu J Cancer 2014 Vol 50, Suppl 6:157). detail...
FGFR2 amp breast cancer sensitive Derazantinib Preclinical - Cell culture Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited growth of breast cancer cells harboring FGFR2 amplification in culture (PMID: 27627808). 27627808
FGFR2 amp myxoid liposarcoma sensitive Dovitinib Preclinical Actionable In a preclinical study, Dovitinib (TKI258) increased apoptosis, inhibited cell proliferation and migration of myxoid liposarcoma cell lines harbors FGFR2 amplification in culture (PMID: 26036639). 26036639
FGFR2 amp colon cancer no benefit Brivanib Preclinical Actionable In a preclinical study, Brivanib (BMS-540215) did not inhibit growth of colon cancer cells harboring FGFR2 amplification in culture (PMID: 22238366). 22238366
FGFR2 amp endometrial cancer sensitive AZD4547 Preclinical - Cell line xenograft Actionable In a preclinical study, AZD4547 inhibited survival of FGFR2 amplified endometrial cancer cells in cell line xenograft models (PMID: 27550940). 27550940
FGFR2 amp colon cancer sensitive BGJ398 Preclinical - Cell culture Actionable In a preclinical study, BGJ398 reduced Myc expression, induced cell-cycle arrest, and inhibited growth of a colon cancer cell line with FGFR2 amplification in culture (PMID: 27401245). 27401245
FGFR2 amp colon cancer sensitive AZD4547 Preclinical - Cell culture Actionable In a preclinical study, AZD4547 inhibited survival of FGFR2 amplified colon cancer cells in culture (PMID: 27550940). 27550940
FGFR2 amp myxoid liposarcoma sensitive Dovitinib + Trabectedin Preclinical Actionable In a preclinical study, Dovitinib (TKI258) and Yondelis (trabectedin) worked synergistically to increase apoptosis, inhibit cell proliferation and migration of myxoid liposarcoma cell lines harbors FGFR2 amplification in culture (PMID: 26036639). 26036639
FGFR2 amp myxoid liposarcoma sensitive BGJ398 Preclinical Actionable In a preclinical study, BGJ398 increased apoptosis, and inhibited cell proliferation and migration of myxoid liposarcoma cell lines harboring FGFR2 amplification in culture (PMID: 26036639). 26036639
FGFR2 amp breast cancer sensitive BGJ398 Phase I Actionable In a Phase I trial, a breast cancer patient harboring an FGFR2 amplification demonstrated stable disease when treated with BGJ398 (PMID: 27870574). 27870574
FGFR2 amp breast cancer sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited Fgfr phosphorylation and cell proliferation in ER-negative breast cancer cells harboring FGFR2 amplification in culture (PMID: 22238366). 22238366
FGFR2 amp stomach cancer sensitive BGJ398 Preclinical Actionable In a preclinical study, BGJ398 inhibited proliferation of gastric cancer cell lines harboring FGFR2 amplification in culture (PMID: 26036639). 26036639
FGFR2 amp myxoid liposarcoma sensitive PD173074 + Trabectedin Preclinical Actionable In a preclinical study, PD173034 and Yondelis (trabectedin) worked synergistically to increase apoptosis, inhibit cell proliferation and migration of myxoid liposarcoma cell lines harboring FGFR2 amplification in culture (PMID: 26036639). 26036639
FGFR2 amp breast cancer sensitive AZD4547 Preclinical - Cell culture Actionable In a preclinical study, AZD4547 inhibited survival of FGFR2 amplified breast cancer cells in culture (PMID: 27550940). 27550940
FGFR2 amp colon cancer sensitive Nintedanib Preclinical Actionable In a preclinical study, Ofev (nintedanib) inhibited growth of colon cancer cells harboring FGFR2 amplification in culture (PMID: 22238366). 22238366
FGFR2 amp stomach cancer resistant Selumetinib Preclinical Actionable In a preclinical study, Selumetinib (AZD-6244) did not inhibit growth of gastric cancer cells with FGFR2 amplification in culture (PMID: 19755509). 19755509
FGFR2 amp colorectal adenocarcinoma predicted - sensitive RO5126766 Preclinical - Cell culture Actionable In a preclinical study, RO5126766 inhibited proliferation of FGFR2 amplified colorectal adenocarcinoma cells in culture (PMID: 26438159). 26438159
FGFR2 amp myxoid liposarcoma sensitive BGJ398 + Trabectedin Preclinical Actionable In a preclinical study, BGJ398 and Yondelis (trabectedin) worked synergistically to increase apoptosis, inhibit cell proliferation and migration of myxoid liposarcoma cell lines harboring FGFR2 amplification in culture (PMID: 26036639). 26036639
FGFR2 amp stomach cancer predicted - sensitive TAS-120 Phase I Actionable In a Phase I trial, TAS-120 treatment resulted in clinical response in a gastric cancer patient harboring FGFR2 amplification (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 372PD). detail...
FGFR2 amp colorectal adenocarcinoma no benefit Selumetinib Preclinical - Cell culture Actionable In a preclinical study, FGFR2 amplified colorectal adenocarcinoma cells were not sensitive to Selumetinib (AZD-6244) in culture (PMID: 26438159). 26438159
FGFR2 amp stomach cancer sensitive Debio 1347 Preclinical - Cell line xenograft Actionable In a preclinical study, Debio 1347 inhibited proliferation of FGFR-amplified gastric cancer cells in culture and inhibited tumor growth in cell line xenograft models of gastric cancer harboring FGFR2 amplification (PMID: 25169980). 25169980
FGFR2 amp stomach cancer sensitive Derazantinib Preclinical - Cell culture Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited Fgfr signaling and growth of gastric cancer cells harboring FGFR2 amplification in culture (PMID: 27627808). 27627808
FGFR2 amp estrogen-receptor negative breast cancer no benefit Brivanib Preclinical Actionable In a preclinical study, Brivanib (BMS-540215) did not inhibit growth of estrogen receptor (ER)-negative breast cancer cells with FGFR2 amplification in culture (PMID: 22238366). 22238366
FGFR2 amp gastric signet ring cell adenocarcinoma sensitive M-COPA Preclinical - Cell culture Actionable In a preclinical study, treatment with M-COPA resulted in decreased Fgfr2 cell surface expression and phosphorylation and reduced growth of an FGFR2-amplified signet cell gastric cancer cell line in culture (PMID: 27197184). 27197184
FGFR2 amp colon cancer sensitive Cediranib Preclinical Actionable In a preclinical study, Cediranib (AZD-2171) inhibited growth of colon cancer cells harboring FGFR2 amplification in culture (PMID: 22238366). 22238366
FGFR2 amp stomach cancer sensitive E7090 Preclinical - Cell line xenograft Actionable In a preclinical study, a gastric cancer cell line harboring FGFR2 amplification demonstrated decreased cell viability in culture and antitumor activity in xenograft models when treated with E7090 (PMID: 27535969). 27535969
FGFR2 amp stomach cancer sensitive PD173074 Preclinical - Cell culture Actionable In a preclinical study, FGFR2-amplified gastric cancer cell lines demonstrated sensitivity to PD173074 in culture, with cell lines with high-level FGFR2 amplification displaying higher sensitivity compared to cell lines with low-level amplification (PMID: 27179038). 27179038
FGFR2 amp stomach cancer sensitive PD173074 Preclinical - Cell culture Actionable In a preclinical study, PD173074 inhibited proliferation of a gastric cancer cell line harboring FGFR2 amplification in culture (PMID: 26036639). 26036639
FGFR2 amp stomach cancer sensitive AZD4547 Phase II Actionable In a Phase II clinical trial, treatment with AZD4547 resulted in a 33% (3/9) response rate in patients with FGFR2-amplified gastroesophageal cancer, and high-level amplification was associated with clinical response (PMID: 27179038). 27179038
FGFR2 amp stomach cancer sensitive AZD4547 Preclinical Actionable In a preclinical study, AZD4547 inhibited FGFR signaling, and decreased proliferation and induced cell-cycle arrest in gastric cancer cells with amplification and over expression of FGFR2 in culture (PMID: 22869148). 22869148
FGFR2 amp stomach cancer sensitive Ponatinib Preclinical - Cell line xenograft Actionable In a preclinical study, Iclusig (ponatinib) inhibited proliferation of FGFR2-amplified gastric cancer cells in culture, and inhibited tumor growth in FGFR2-amplified gastric cancer cell line xenograft models (PMID: 22238366). 22238366
FGFR2 amp stomach cancer sensitive FIIN-01 Preclinical Actionable In a preclinical study, FIIN-01 inhibited Fgfr2-dependent cell proliferation of gastric cancer cell lines harboring FGFR2 amplification (PMID: 20338520). 20338520
FGFR2 amp Advanced Solid Tumor predicted - sensitive AZD4547 Phase II Actionable In a Phase II (MATCH) trial, AZD4547 treatment resulted in stable disease in 59% (10/17) of patients with advanced solid tumors harboring FGFR amplification, with a 6-month progression-free survival rate of 15% (J Clin Oncol 36, 2018 (suppl; abstr 2503); NCT02465060). detail...
FGFR2 amp stomach cancer sensitive ODM-203 Preclinical - Cell line xenograft Actionable In a preclinical study, ODM-203 inhibited FGFR signaling and proliferation in a gastric cancer cell line with amplification of FGFR2, and inhibited tumor growth in xenograft models (PMID: 30301864). 30301864
FGFR2 amp myxoid liposarcoma sensitive PD173074 Preclinical Actionable In a preclinical study, PD173074 increased apoptosis, inhibited cell proliferation and migration of myxoid liposarcoma cell lines harboring FGFR2 amplification in culture (PMID: 26036639). 26036639
FGFR2 amp ovarian cancer sensitive BAY1187982 Preclinical - Pdx Actionable In a preclinical study, BAY1187982 inhibited tumor growth in patient-derived xenograft models of FGFR2 amplified ovarian cancer (PMID: 27543601). 27543601
FGFR2 amp breast cancer sensitive Debio 1347 Preclinical Actionable In a preclinical study, Debio 1347 inhibited proliferation of breast cancer cell lines harboring FGFR2 amplification in culture (PMID: 25169980). 25169980
FGFR2 amp colorectal cancer sensitive Debio 1347 Preclinical Actionable In a preclinical study, Debio 1347 inhibited proliferation of colorectal cancer cell lines harboring FGFR2 amplification in culture (PMID: 25169980). 25169980
FGFR2 amp stomach cancer sensitive Erdafitinib Preclinical - Cell line xenograft Actionable In a preclinical study, JNJ-42756493 (erdafitinib) inhibited proliferation of a gastric cancer cell line with FGFR2 amplification in culture, and inhibited tumor growth in xenograft models (PMID: 28341788). 28341788
FGFR2 amp colorectal cancer sensitive Erdafitinib Preclinical - Cell line xenograft Actionable In a preclinical study, Erdafitinib (JNJ-42756493) inhibited tumor growth in an FGFR2-amplified colorectal cancer cell line xenograft model (PMID: 28341788). 28341788
FGFR2 amp stomach cancer sensitive Cediranib Preclinical Actionable In a preclinical study, Cediranib (AZD-2171) inhibited growth of gastric cancer cells harboring FGFR2 amplification in culture (PMID: 22238366). 22238366
FGFR2 amp stomach carcinoma no benefit RO4987655 Preclinical - Cell culture Actionable In a preclinical study, FGFR2 amplified gastric carcinoma cell lines were not sensitive to RO4987655 in culture (PMID: 26438159). 26438159
FGFR2 amp breast cancer sensitive Dovitinib Preclinical - Pdx & cell culture Actionable In a preclinical study, Dovitinib (TKI258) inhibited cell growth of an FGFR2 amplified breast cancer cell line in culture and prevented tumor growth and induced tumor regression in FGFR2 amplified breast cancer patient derived xenograft (PDX) models (PMID: 23658459). 23658459
FGFR2 amp stomach carcinoma sensitive Debio 1347 Preclinical - Cell line xenograft Actionable In a preclinical study, Debio 1347 inhibited tumor growth in cell line xenograft models of FGFR2 amplified gastric carcinoma (PMID: 26438159). 26438159
FGFR2 amp colon cancer sensitive Dovitinib Preclinical Actionable In a preclinical study, Dovitinib (TKI258) inhibited cell proliferation in colon cancer cells harboring FGFR2 amplification in culture (PMID: 22238366). 22238366
FGFR2 amp colorectal adenocarcinoma decreased response RO4987655 Preclinical - Cell culture Actionable In a preclinical study, FGFR2 amplified colorectal adenocarcinoma cells demonstrated decreased response to RO4987655 in culture (PMID: 26438159). 26438159
FGFR2 amp stomach cancer sensitive Dovitinib Preclinical Actionable In a preclinical study, Dovitinib (TKI258) inhibited cell proliferation in gastric cancer cell lines harboring FGFR2 amplification in culture (PMID: 22238366). 22238366
FGFR2 amp stomach cancer no benefit Brivanib Preclinical Actionable In a preclinical study, Brivanib (BMS-540215) did not inhibit growth of gastric cancer cells harboring FGFR2 amplification in culture (PMID: 22238366). 22238366
FGFR2 amp stomach carcinoma no benefit RO5126766 Preclinical - Cell culture Actionable In a preclinical study, FGFR2 amplified gastric carcinoma cell lines were not sensitive to RO5126766 in culture (PMID: 26438159). 26438159
FGFR2 amp non-small cell lung carcinoma sensitive PRN1371 Preclinical - Pdx Actionable In a preclinical study, PRN1371 treatment resulted in 67.5% tumor growth inhibition in patient-derived xenograft models of FGFR2-amplified non-small cell lung cancer (PMID: 28978721). 28978721
FGFR2 amp stomach carcinoma sensitive PRN1371 Preclinical - Cell line xenograft Actionable In a preclinical study, PRN1371 inhibited proliferation of FGFR2 amplified gastric carcinoma cells in culture and tumor growth in cell line xenograft models (PMID: 28978721). 28978721
FGFR2 amp colon cancer sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited Fgfr phosphorylation and cell proliferation in colon cancer cells harboring FGFR2 amplification in culture (PMID: 22238366). 22238366
FGFR2 amp gastric adenocarcinoma no benefit AZD4547 Phase II Actionable In a Phase II trial (SHINE), AZD4547 treatment did not improve progression-free survival compared to Taxol (paclitaxel) (1.8 vs 3.5 months, p=0.9581) in advanced gastric adenocarcinoma patients with FGFR2 amplification (PMID: 29177434; NCT01457846). 29177434
FGFR1 amp FGFR2 amp breast cancer sensitive E7090 Preclinical - Cell line xenograft Actionable In a preclinical study, a breast cancer cell line, harboring FGFR1 amplification and FGFR2 amplification, treated with E7090 demonstrated decreased cell viability in culture and antitumor activity in xenograft models (PMID: 27535969). 27535969
FGFR2 amp FGFR2-GAB2 breast cancer sensitive PRN1371 Preclinical - Pdx Actionable In a preclinical study, PRN1371 treatment resulted in 60.6% tumor growth inhibition in patient-derived xenograft models of breast cancer harboring FGFR2 amplification and FGFR2-GAB2 fusion (PMID: 28978721). 28978721
ERBB2 amp FGFR2 amp esophagus adenocarcinoma sensitive AZD4547 + Lapatinib Preclinical - Cell culture Actionable In a preclinical study, the combination of AZD-4547 and Tykerb (lapatinib) worked synergistically to inhibit growth of an esophageal adenocarcinoma cell line with ERBB2 (HER2) and FGFR2 amplification in culture (PMID: 27595477). 27595477
FGFR2 amp FGFR2 rearrange cholangiocarcinoma predicted - sensitive TAS-120 Phase I Actionable In a Phase I trial, TAS-120 treatment resulted in partial response in a patient with cholangiocarcinoma harboring FGFR2 rearrangement and FGFR2 amplification (Annals of Oncology, Volume 29, Issue suppl_5). detail...
FGFR2 amp FGFR2-COL14A1 colorectal adenocarcinoma sensitive PRN1371 Preclinical - Cell culture Actionable In a preclinical study, PRN1371 inhibited proliferation of colorectal adenocarcinoma cells harboring FGFR2 amplification and FGFR2-COL14A1 fusion in culture (PMID: 28978721). 28978721
FGFR2 amp FGFR2-COL14A1 colon cancer sensitive Derazantinib Preclinical - Cell line xenograft Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited Fgfr signaling and growth of colon cancer cells harboring FGFR2 amplification and FGFR2-COL14A1 fusion in culture and in cell line xenograft models (PMID: 27627808). 27627808
FGFR2 amp FGFR2 fusion stomach cancer sensitive Derazantinib Preclinical - Cell line xenograft Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited Fgfr signaling and growth of gastric cancer cells harboring FGFR2 amplification and PDHX-FGFR2 fusion in culture, resulted in tumor regression in cell line xenograft models (PMID: 27627808). 27627808
FGFR2 amp FGFR2 fusion breast cancer sensitive PRN1371 Preclinical - Pdx Actionable In a preclinical study, PRN1371 treatment resulted in tumor growth inhibition in patient-derived xenograft models of FGFR2-amplified breast cancer harboring FGFR2-GAB2 fusion (AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1249). detail...
FGFR2 K310R FGFR2 N549K endometrial cancer sensitive Debio 1347 Preclinical Actionable In a preclinical study, Debio 1347 inhibited proliferation of endometrial cancer cells harboring FGFR2 K310R and FGFR2 N549K mutations in culture (PMID: 25169980). 25169980
FGFR2 K310R FGFR2 N549K endometrial carcinoma no benefit RO4987655 Preclinical - Cell culture Actionable In a preclinical study, endometrial carcinoma cells harboring both FGFR2 K310R and N549K were not sensitive to RO4987655 in culture (PMID: 26438159). 26438159
FGFR2 K310R FGFR2 N549K endometrial carcinoma no benefit Selumetinib Preclinical - Cell culture Actionable In a preclinical study, endometrial carcinoma cells harboring both FGFR2 K310R and N549K were not sensitive to Selumetinib (AZD-6244) in culture (PMID: 26438159). 26438159
FGFR2 K310R FGFR2 N549K endometrial carcinoma no benefit RO5126766 Preclinical - Cell culture Actionable In a preclinical study, endometrial carcinoma cells harboring both FGFR2 K310R and N549K were not sensitive to RO5126766 in culture (PMID: 26438159). 26438159
FGFR2 K310R FGFR2 N549K endometrial carcinoma sensitive FIIN-01 Preclinical Actionable In a preclinical study, FIIN-01 inhibited proliferation of endometrial carcinoma cell lines harboring FGFR2 N549K and FGFR2 K310R mutations in culture (PMID: 20338520). 20338520
FGFR2 N549K endometrial cancer decreased response Dovitinib Preclinical Actionable In a preclinical study, Dovitinib (TKI258) did not potently inhibit proliferation of endometrial cancer cell lines harboring FGFR2 N549K in cell culture (PMID: 22238366). 22238366
FGFR2 N549K endometrial carcinoma no benefit Selumetinib Preclinical - Cell culture Actionable In a preclinical study, endometrial carcinoma cells harboring FGFR2 N549K were not sensitive to Selumetinib (AZD-6244) in culture (PMID: 26438159). 26438159
FGFR2 N549K endometrial cancer sensitive Debio 1347 Preclinical Actionable In a preclinical study, Debio 1347 inhibited proliferation of endometrial cancer cells harboring FGFR2 N549K mutation in culture (PMID: 25169980). 25169980
FGFR2 N549K endometrial cancer sensitive Cediranib Preclinical Actionable In a preclinical study, Cediranib (AZD-2171) inhibited growth of endometrial cancer cells harboring FGFR2 N549K in cell culture (PMID: 22238366). 22238366
FGFR2 N549K endometrial cancer sensitive Derazantinib Preclinical - Cell culture Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited growth of endometrial cancer cell lines harboring FGFR2 N549K in culture (PMID: 27627808). 27627808
FGFR2 N549K endometrial carcinoma sensitive FIIN-01 Preclinical Actionable In a preclinical study, FIIN-01 inhibited proliferation of endometrial carcinoma cell lines harboring FGFR2 N549K mutation in culture (PMID: 20338520). 20338520
FGFR2 N549K endometrial adenocarcinoma sensitive PRN1371 Preclinical - Cell culture Actionable In a preclinical study, PRN1371 inhibited proliferation of endometrial adenocarcinoma cells harboring FGFR2 N549K in culture (PMID: 28978721). 28978721
FGFR2 N549K endometrial cancer sensitive Ponatinib Preclinical - Cell line xenograft Actionable In a preclinical study, Iclusig (ponatinib) inhibited growth of endometrial cancer cells harboring FGFR2 N549K in culture and in cell line xenograft models (PMID: 22238366). 22238366
FGFR2 N549K endometrial cancer no benefit Brivanib Preclinical Actionable In a preclinical study, Brivanib (BMS-540215) did not inhibit growth of endometrial cancer cells harboring FGFR2 N549K in cell culture (PMID: 22238366). 22238366
FGFR2 N549K endometrial carcinoma no benefit RO4987655 Preclinical - Cell culture Actionable In a preclinical study, endometrial carcinoma cells harboring FGFR2 N549K were not sensitive to RO4987655 in culture (PMID: 26438159). 26438159
FGFR2 N549K endometrial cancer resistant Nintedanib Preclinical Actionable In a preclinical study, Ofev (Nintedanib) did not inhibit growth of endometrial cancer cells harboring FGFR2 N549K in cell culture (PMID: 22238366). 22238366
FGFR2 N549K endometrial carcinoma no benefit RO5126766 Preclinical - Cell culture Actionable In a preclinical study, endometrial carcinoma cells harboring FGFR2 N549K were not sensitive to RO5126766 in culture (PMID: 26438159). 26438159
FGFR2 N550H Advanced Solid Tumor resistant PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 N550H were resistant to treatment with PD173074 (PMID: 23908597). 23908597
FGFR2 N550H Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited Fgfr2 phosphorylation and proliferation in transformed cells expressing FGFR2 N550H (PMID: 23908597). 23908597
FGFR2 N550H Advanced Solid Tumor decreased response Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 N550H demonstrated a decreased response to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 positive breast cancer predicted - sensitive Rogaratinib Phase I Actionable In a Phase I trial, sensitivity to treatment with Rogaratinib (BAY 1163877) was demonstrated in patients with a variety of FGFR-expressing solid tumor types, including long lasting stable disease in a patient with FGFR2-positive breast cancer (Ann Oncol 2017, Vol 28, Suppl 5, Abstract #379P; NCT01976741). detail...
FGFR2 positive Advanced Solid Tumor sensitive BAY1187982 Preclinical - Pdx & cell culture Actionable In a preclinical study, sensitivity to BAY1187982 positively correlated with Fgfr2 expression level in a variety of cancer cell lines in culture, and in cell line or patient-derived xenograft models (PMID: 27543601). 27543601
FGFR2 positive stomach cancer sensitive BAY1187982 Preclinical - Pdx & cell culture Actionable In a preclinical study, BAY1187982 inhibited survival of gastric cancer cell lines with elevated Fgfr2 expression level in culture, and suppressed tumor growth in cell line or patient-derived xenograft models (PMID: 27543601). 27543601
FGFR2 positive breast cancer sensitive BAY1187982 Preclinical - Pdx & cell culture Actionable In a preclinical study, BAY1187982 inhibited survival of Fgfr2 positive breast cancer cell lines in culture, and suppressed tumor growth in both cell line and patient-derived xenograft models (PMID: 27543601). 27543601
FGFR2 pos FGFR3 pos breast carcinoma sensitive E7090 Preclinical Actionable In a preclinical study, a mouse breast carcinoma cell line xenograft model demonstrated inhibition of tumor growth when treated with E7090, a result of decreased FGFR2 and FGFR3 activity (PMID: 27535969). 27535969
FGFR1 pos FGFR2 pos hepatocellular carcinoma no benefit PHA-665752 Preclinical - Cell culture Actionable In a preclinical study, PHA-665752 treatment did not result in decreased colony formation or reduced phosphorylation levels of FGFR1 and FGFR2 in hepatocellular carcinoma cells in culture (PMID: 26351320). 26351320
FGFR1 pos FGFR2 pos hepatocellular carcinoma sensitive AZD4547 Preclinical - Cell culture Actionable In a preclinical study, hepatocellular carcinoma cell lines treated with AZD4547 demonstrated decreased phosphorylation of FGFR1 and FGFR2, reduced colony formation, and evidence of apoptotic activity in culture (PMID: 26351320). 26351320
FGFR2 wild-type ERBB2 amp stomach cancer resistant AZD4547 Preclinical Actionable In a preclinical study, gastric cancer cells with wild-type FGFR2 and ERBB2 (HER2) amplification were resistant to treatment with AZD4547 in culture (PMID: 22869148). 22869148
FGFR2 wild-type breast cancer resistant Ponatinib Preclinical Actionable In a preclinical study, ER-negative breast cancer cells with wild-type FGFR2 were resistant to growth inhibition by Iclusig (ponatinib) in cell culture (PMID: 22238366). 22238366
FGFR2 wild-type endometrial cancer resistant AZD4547 Preclinical - Cell culture Actionable In a preclinical study, endometrial cells with Fgfr2 wild-type were resistant to the anti-proliferative effects of AZD4547 (PMID: 26294741). 26294741
FGFR2 wild-type endometrial carcinoma resistant FIIN-01 Preclinical Actionable In a preclinical study, an endometrial carcinoma cell line harboring wild-type FGFR2 was resistant to FIIN-01-induced growth inhibition in culture (PMID: 20338520). 20338520
FGFR2 wild-type Advanced Solid Tumor predicted - sensitive AZ6089 Preclinical Actionable In a preclinical study, AZ12576089 (AZ6089) inhibited FGF2-induced ERK1/2 phosphorylation and cell proliferation in transformed fibroblasts in culture (PMID: 22869148). 22869148
FGFR2 wild-type colon cancer resistant Ponatinib Preclinical Actionable In a preclinical study, colon cancer cells with wild-type FGFR2 were resistant to growth inhibition by Iclusig (ponatinib) in cell culture (PMID: 22238366). 22238366
FGFR2 wild-type stomach cancer resistant Ponatinib Preclinical Actionable In a preclinical study, gastric cancer cells with wild-type FGFR2 were resistant to growth inhibition by Iclusig (ponatinib) in cell culture (PMID: 22238366). 22238366
FGFR2 wild-type endometrial cancer resistant Ponatinib Preclinical Actionable In a preclinical study, endometrial cancer cells with wild-type FGFR2 were resistant to growth inhibition by Iclusig (ponatinib) in cell culture (PMID: 22238366). 22238366
FGFR2 wild-type Advanced Solid Tumor sensitive PRN1371 Preclinical - Cell culture Actionable In a preclinical study, PRN1371 inhibited Fgfr2 activity in transformed cells over expressing wild-type Fgfr2 in culture (AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1249). detail...
FGFR2 M538I Advanced Solid Tumor decreased response Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 M538I demonstrated a decreased response to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 M538I Advanced Solid Tumor decreased response PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 M538I demonstrated a decreased response to treatment with PD173074 (PMID: 23908597). 23908597
FGFR2 M538I Advanced Solid Tumor decreased response Ponatinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 M538I demonstrated a decreased response to treatment with Iclusig (ponatinib) (PMID: 23908597). 23908597
FGFR2 K310R FGFR2 N550K endometrial cancer sensitive AZD4547 Preclinical - Pdx & cell culture Actionable In a preclinical study, AZD4547 inhibited proliferation of endometrial cells and delayed tumor growth in cell-line derived xenografts harboring the Fgfr2 double mutant, K310R, N550K (PMID: 26294741). 26294741
FGFR2 N550K Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited Fgfr2 phosphorylation and proliferation in transformed cells expressing FGFR2 N550K (PMID: 23908597). 23908597
FGFR2 N550K endometrial cancer decreased response AZD4547 Preclinical - Cell culture Actionable In a preclinical study, endometrial cells harboring Fgfr2 N550K were less sensitive to the anti-proliferative effects of AZD4547 than the Fgfr2 double mutant, K310R, N550K (PMID: 26294741). 26294741
FGFR2 N550K Advanced Solid Tumor resistant PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 N550K were resistant to PD173074 (PMID: 23908597). 23908597
FGFR2 N550K Advanced Solid Tumor resistant Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 N550K were resistant to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 N550K Advanced Solid Tumor sensitive PRN1371 Preclinical - Cell culture Actionable In a preclinical study, PRN1371 inhibited proliferation of transformed cells over expressing FGFR2 N550K in culture (PMID: 28978721). 28978721
FGFR2 C383R FGFR2 N550K endometrial cancer resistant PD173074 Preclinical Actionable In a preclinical study, an endometrial cancer cell line harboring FGFR2 C383R and expressing FGFR2 N550K demonstrated resistance when treated with PD173074 (PMID: 23908597). 23908597
FGFR2 V564L Advanced Solid Tumor resistant Debio 1347 Preclinical - Cell culture Actionable In a preclinical study, Debio 1347 did not inhibit Fgfr2 phosphorylation in transformed cells over expressing FGFR2 V564L in culture (PMID: 25169980). 25169980
FGFR2 S252W endometrial cancer sensitive Brivanib Preclinical Actionable In a preclinical study, Brivanib (BMS-540215) inhibited growth of endometrial cancer cells harboring FGFR2 S252W in culture (PMID: 22238366). 22238366
FGFR2 S252W endometrial cancer sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited Fgfr2 phosphorylation and cell proliferation in endometrial cancer cells harboring FGFR2 S252W in culture (PMID: 22238366). 22238366
FGFR2 S252W endometrial carcinoma decreased response Selumetinib Preclinical - Cell culture Actionable In a preclinical study, endometrial carcinoma cells harboring FGFR2 S252W demonstrated decreased sensitivity to Selumetinib (AZD-6244) in culture (PMID: 26438159). 26438159
FGFR2 S252W endometrial cancer sensitive Derazantinib Preclinical - Cell culture Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited growth of endometrial cancer cells harboring FGFR2 S252W in culture (PMID: 27627808). 27627808
FGFR2 S252W endometrial cancer decreased response Dovitinib Preclinical Actionable In a preclinical study, Dovitinib (TKI258) did not potently inhibit cell proliferation in endometrial cancer cells harboring FGFR2 S252W mutation in culture (PMID: 22238366). 22238366
FGFR2 S252W endometrial cancer sensitive Debio 1347 Preclinical - Cell line xenograft Actionable In a preclinical study, Debio 1347 inhibited proliferation of endometrial cancer cells harboring an FGFR2 S252W mutation in culture and inhibited tumor growth in FGFR2 S252W-positive endometrial cancer cell line xenograft models (PMID: 25169980). 25169980
FGFR2 S252W endometrial cancer sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, an endometrial cancer cell line harboring FGFR2 S252W (PMID: 18552176) demonstrated sensitivity to E7090 in culture, resulting in decreased cell viability (PMID: 27535969). 18552176 27535969
FGFR2 S252W Advanced Solid Tumor sensitive Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 S252W were sensitive to Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 S252W endometrial cancer sensitive Nintedanib Preclinical Actionable In a preclinical study, Ofev (Nintedanib) inhibited cell proliferation in endometrial cancer cells harboring FGFR2 S252W mutation in culture (PMID: 22238366). 22238366
FGFR2 S252W endometrial carcinoma decreased response RO4987655 Preclinical - Cell culture Actionable In a preclinical study, endometrial carcinoma cells harboring FGFR2 S252W demonstrated decreased response to RO4987655 in culture (PMID: 26438159). 26438159
FGFR2 S252W endometrial carcinoma sensitive RO5126766 Preclinical - Cell culture Actionable In a preclinical study, RO5126766 inhibited proliferation of endometrial carcinoma cells harboring FGFR2 S252W in culture (PMID: 26438159). 26438159
FGFR2 S252W endometrial cancer sensitive Cediranib Preclinical Actionable In a preclinical study, Cediranib (AZD-2171) inhibited growth of endometrial cancer cells harboring FGFR2 S252W in culture (PMID: 22238366). 22238366
FGFR2 S252W endometrial carcinoma sensitive GSK3052230 Preclinical - Cell line xenograft Actionable In a preclinical study, GSK3052230 (FP-1039) treatment resulted in greater tumor growth inhibition (95% vs 30%) in cell line xenograft models of endometrial carcinoma harboring FGFR2 S252W compared to FGFR2 wild-type models (PMID: 23536011). 23536011
FGFR2 S252W endometrial cancer decreased response AZD4547 Preclinical - Cell culture Actionable In a preclinical study, endometrial cells harboring Fgfr2 S252W were less sensitive to the anti-proliferative effects of AZD4547 than the Fgfr2 double mutant, K310R, N550K (PMID: 26294741). 26294741
FGFR2 fusion FGFR2 V564F cholangiocarcinoma predicted - resistant BGJ398 Clinical Study Actionable In a clinical study, FGFR2 V564F was identified in the cell-free DNA of 3 cholangiocarcinoma patients harboring FGFR2 fusion after the patients progressed while on BGJ398 treatment (PMID: 28034880). 28034880
FGFR2 fusion FGFR3 - TACC3 adrenal carcinoma sensitive Erdafitinib Phase I Actionable In a Phase I trial, Erdafitinib (JNJ-42756493) treatment resulted tumor shrinkage and no disease progression for 10 months in an adrenal carcinoma patient harboring FGFR3 - TACC3 and FGFR2 - CCDC6 fusions (PMID: 26324363). 26324363
FGFR2 fusion Advanced Solid Tumor predicted - sensitive AZD4547 Phase II Actionable In a Phase II (MATCH) trial, AZD4547 treatment resulted in partial response in 22% (2/9) and stable disease in 55% (5/9) of patients with advanced solid tumors harboring FGFR fusions, with a 6-month progression-free survival rate of 42% (J Clin Oncol 36, 2018 (suppl; abstr 2503); NCT02465060). detail...
FGFR2 fusion biliary tract cancer predicted - sensitive TAS-120 Phase I Actionable In a Phase I trial, TAS-120 treatment resulted in stable disease over 24 weeks in two biliary tract cancer patients harboring FGFR2 fusions (Ann Oncol 2017, Vol 28, Suppl 5, Abstract # 372PD). detail...
FGFR2 fusion cholangiocarcinoma predicted - sensitive TAS-120 Phase I Actionable In a Phase I trial, TAS-120 treatment resulted in an objective response rate of 25% (7/28, 7 partial responses) in patients with cholangiocarcinoma harboring FGFR2 fusions, with 71% of patients experienced tumor shrinkage, 54% (15/28) achieved stable disease (Annals of Oncology, Volume 29, Issue suppl_5). detail...
FGFR2 fusion intrahepatic cholangiocarcinoma sensitive Derazantinib Phase I Actionable In a Phase I trial, Derazantinib (ARQ 087) treatment resulted in partial response in 2 and stable disease in 1 of the 5 intrahepatic cholangiocarcinoma patients harboring FGFR2 fusions, and progressive disease in 5 patients without FGFR aberrations (PMID: 28972963; NCT01752920). detail... 28972963
FGFR2 fusion cholangiocarcinoma sensitive BGJ398 Phase I Actionable In a Phase I trial, two patients with cholangiocarcinoma harboring FGFR2 fusions demonstrated a decreased tumor burden when treated with BGJ398 (PMID: 27870574). 27870574
FGFR2 fusion urinary system cancer sensitive Erdafitinib Phase I Actionable In a Phase I trial, Erdafitinib (JNJ-42756493) treatment resulted in partial response for more than 12 months in a urothelial cancer patient harboring FGFR2 - BICC1 and FGFR2 - CASP7 fusions (PMID: 26324363). 26324363
FGFR2 fusion endometrial cancer sensitive Erdafitinib Phase I Actionable In a Phase I trial, Erdafitinib (JNJ-42756493) treatment resulted in partial response in an endometrial cancer patient harboring FGFR2 - BICC1 and FGFR2 - OFD1 fusions (PMID: 26324363). 26324363
FGFR2 K660N Advanced Solid Tumor sensitive AZD4547 Preclinical - Cell culture Actionable In a preclinical study, AZD4547 inhibited growth of transformed cells expressing FGFR2 K660N in culture (PMID: 23786770). 23786770
FGFR2 K660N Advanced Solid Tumor sensitive Ponatinib Preclinical - Cell culture Actionable In a preclinical study, Iclusig (ponatinib) inhibited growth of transformed cells expressing FGFR2 K660N in culture (PMID: 23786770). 23786770
FGFR2 K660N Advanced Solid Tumor sensitive BGJ398 Preclinical - Cell line xenograft Actionable In a preclinical study, BGJ398 inhibited growth of transformed cells expressing FGFR2 K660N in culture and inhibited tumor growth in xenograft models (PMID: 23786770). 23786770
FGFR2 K660N Advanced Solid Tumor sensitive Pazopanib Preclinical - Cell culture Actionable In a preclinical study, Votrient (pazopanib) inhibited growth of transformed cells expressing FGFR2 K660N in culture (PMID: 23786770). 23786770
FGFR2 K660N Advanced Solid Tumor sensitive Lenvatinib Preclinical - Cell culture Actionable In a preclinical study, Lenvima (lenvatinib) inhibited growth of transformed cells expressing FGFR2 K660N in culture (PMID: 23786770). 23786770
FGFR2 K660N Advanced Solid Tumor sensitive Cediranib Preclinical - Cell culture Actionable In a preclinical study, Cediranib (AZD-2171) inhibited growth of transformed cells expressing FGFR2 K660N in culture (PMID: 23786770). 23786770
FGFR2 K660N Advanced Solid Tumor sensitive PRN1371 Preclinical - Cell culture Actionable In a preclinical study, PRN1371 inhibited proliferation of transformed cells over expressing FGFR2 K660N in culture (PMID: 28978721). 28978721 detail...
BRCA1 loss FGFR2-DNM3 triple-receptor negative breast cancer sensitive BGJ398 + Talazoparib Preclinical - Cell line xenograft Actionable In a preclinical study, BRCA1-deficient triple-receptor negative breast cancer xenograft models treated with a combination of BGJ398 and Talazoparib (BMN-673) demonstrated a complete response and no relapse within 80 days (PMID: 29203461). 29203461
BRCA1 loss FGFR2-DNM3 triple-receptor negative breast cancer sensitive BGJ398 + Olaparib Preclinical - Cell line xenograft Actionable In a preclinical study, BRCA1-deficient triple-receptor negative breast cancer xenograft models harboring FGFR2-DNM3 treated with a combination of BGJ398 and Lynparza (olaparib) demonstrated a complete response and did not develop resistance as compared to those models treated with BGJ398 alone (PMID: 29203461). 29203461
BRCA1 loss FGFR2-DNM3 triple-receptor negative breast cancer decreased response Buparlisib Preclinical - Cell line xenograft Actionable In a preclinical study, BRCA1-deficient triple-receptor negative breast cancer xenograft models treated with BKM120 demonstrated only delayed tumor progression when compared to treatment with BGJ398, which resulted in tumor regression (PMID: 29203461). 29203461
BRCA1 loss FGFR2-DNM3 triple-receptor negative breast cancer predicted - sensitive BGJ398 Preclinical - Cell line xenograft Actionable In a preclinical study, BRCA1-deficient triple-receptor negative breast cancer xenograft models harboring FGFR2-DNM3 were sensitive to treatment with BGJ398, demonstrating tumor regression, however, after 43 days on average, three out of six models developed resistance (PMID: 29203461). 29203461
FGFR2 - CIT Advanced Solid Tumor sensitive Derazantinib Preclinical - Cell culture Actionable In a preclinical study, Derazantinib (ARQ 087) inhibited growth of transformed cells expressing FGFR2-CIT in culture (PMID: 27627808). 27627808
FGFR2 N550S Advanced Solid Tumor decreased response Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 N550S demonstrated a decreased response to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 N550S Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited Fgfr2 phosphorylation and proliferation in transformed cells expressing FGFR2 N550S (PMID: 23908597). 23908597
FGFR2 N550S Advanced Solid Tumor decreased response PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 N550S demonstrated a decreased response to treatment with PD173074 (PMID: 23908597). 23908597
FGFR2 K660E Advanced Solid Tumor sensitive Lenvatinib Preclinical - Cell culture Actionable In a preclinical study, Lenvima (lenvatinib) inhibited growth of transformed cells expressing FGFR2 K660E in culture (PMID: 23786770). 23786770
FGFR2 K660E Advanced Solid Tumor sensitive Cediranib Preclinical - Cell culture Actionable In a preclinical study, Cediranib (AZD-2171) inhibited growth of transformed cells expressing FGFR2 K660E in culture (PMID: 23786770). 23786770
FGFR2 K660E Advanced Solid Tumor resistant Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 K660E were resistant to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 K660E Advanced Solid Tumor sensitive AZD4547 Preclinical - Cell culture Actionable In a preclinical study, AZD4547 inhibited growth of transformed cells expressing FGFR2 K660E in culture (PMID: 23786770). 23786770
FGFR2 K660E Advanced Solid Tumor sensitive Ponatinib Preclinical - Cell culture Actionable In a preclinical study, Iclusig (ponatinib) inhibited growth of transformed cells expressing FGFR2 K660E in culture (PMID: 23908597). 23908597
FGFR2 K660E Advanced Solid Tumor sensitive BGJ398 Preclinical - Cell culture Actionable In a preclinical study, BGJ398 inhibited growth of transformed cells expressing FGFR2 K660E in culture (PMID: 23786770). 23786770
FGFR2 K660E Advanced Solid Tumor sensitive Pazopanib Preclinical - Cell culture Actionable In a preclinical study, Votrient (pazopanib) inhibited growth of transformed cells expressing FGFR2 K660E in culture (PMID: 23786770). 23786770
FGFR2 K660E Advanced Solid Tumor decreased response PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 K660E demonstrated a decreased response when treated with PD173074 (PMID: 23908597). 23908597
FGFR2 K660E Advanced Solid Tumor sensitive PRN1371 Preclinical - Cell culture Actionable In a preclinical study, PRN1371 inhibited proliferation of transformed cells over expressing FGFR2 K660E in culture (PMID: 28978721). 28978721 detail...
FGFR2-FAM76A ovarian cancer sensitive BGJ398 Preclinical - Patient cell culture Actionable In a preclincal study, BGJ398 demonstrated enhanced inhibition of the survival in patient-derived ovarian cancer cells harboring FGFR2 - FAM76A in culture (PMID: 24563622). 24563622
FGFR2 V564I Advanced Solid Tumor resistant Debio 1347 Preclinical - Cell culture Actionable In a preclinical study, Debio 1347 did not inhibit Fgfr2 phosphorylation in transformed cells over expressing FGFR2 V564I in culture (PMID: 25169980). 25169980
FGFR2 rearrange cholangiocarcinoma resistant Pemigatinib Phase II Actionable In a Phase II (FIGHT-202) trial, Pemigatinib (INCB054828) treatment resulted in partial response in 18% (8/45, 1 unconfirmed complete response), stable disease in 58% (26/45) of patients with cholangiocarcinoma harboring FGFR2 translocations, with a median progression-free survival of 6.8 months; and no response were observed in cohorts of patients with other FGF/FGFR genetic alterations or wild-type FGF/FGFR (Ann Oncol, Oct 2018, 29 (suppl 8), abstract 756P; NCT02924376). detail...
FGFR2 rearrange cholangiocarcinoma predicted - sensitive TAS-120 Phase I Actionable In a Phase I trial, TAS-120 treatment resulted in partial response in 2 patients with cholangiocarcinoma harboring FGFR2 rearrangements (Annals of Oncology, Volume 29, Issue suppl_5). detail...
FGFR2-AHCYL1 Advanced Solid Tumor sensitive PD173074 Preclinical Actionable In a preclinical study, treatment with PD173074 prevented transformation of cells expressing FGFR2-AHCYL1 in culture (PMID: 24122810). 24122810
FGFR2-AHCYL1 Advanced Solid Tumor sensitive BGJ398 Preclinical Actionable In a preclinical study, treatment with BGJ398 prevented transformation of cells expressing FGFR2-AHCYL1 in culture (PMID: 24122810). 24122810
FGFR2 I548V Advanced Solid Tumor decreased response Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 I548V demonstrated a decreased response to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 I548V Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited Fgfr2 phosphorylation and proliferation in transformed cells expressing FGFR2 I548V (PMID: 23908597). 23908597
FGFR2 I548V Advanced Solid Tumor decreased response PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 I548V demonstrated a decreased response to treatment with PD173074 (PMID: 23908597). 23908597
FGFR2-TNS1 triple-receptor negative breast cancer sensitive BGJ398 + BKM120 Preclinical - Cell line xenograft Actionable In a preclinical study, triple-receptor negative breast cancer xenograft models harboring FGFR2-TNS1 demonstrated rapid and complete tumor regression when treated with the combination of BGJ398 and Buparlisib (BKM120) (PMID: 29203461). 29203461
FGFR2-TNS1 triple-receptor negative breast cancer sensitive BGJ398 Preclinical - Cell line xenograft Actionable In a preclinical study, triple-receptor negative breast cancer xenograft models harboring FGFR2-TNS1 demonstrated tumor regression when treated with BGJ398 (PMID: 29203461). 29203461
FGFR2-TNS1 triple-receptor negative breast cancer no benefit Buparlisib Preclinical - Cell line xenograft Actionable In a preclinical study, triple-receptor negative breast cancer xenograft models harboring FGFR2-TNS1 demonstrated stable disease upon treatment with Buparlisib (BKM120), but also exhibited general toxicity (PMID: 29203461). 29203461
FGFR2 V565I Advanced Solid Tumor resistant PD173074 Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 V565I were resistant to treatment with PD173074 (PMID: 23908597). 23908597
FGFR2 V565I Advanced Solid Tumor resistant Dovitinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 V565I were resistant to treatment with Dovitinib (TKI258) (PMID: 23908597). 23908597
FGFR2 V565I Advanced Solid Tumor resistant Ponatinib Preclinical Actionable In a preclinical study, transformed cells expressing FGFR2 V565I were resistant to treatment with Iclusig (ponatinib) (PMID: 23908597). 23908597
FGFR2 - TACC3 Advanced Solid Tumor sensitive Ponatinib Preclinical Actionable In a preclinical study, Iclusig (ponatinib) inhibited downstream phosphorylation of Akt and Erk1/2 in cells expressing the fusion, FGFR2 - TACC3 (PMID: 26048680). 26048680
FGFR2 - TACC3 Advanced Solid Tumor sensitive BGJ398 Preclinical Actionable In a preclinical study, BGJ398 prevented oncogenic transformation of cells expressing FGFR2 - TACC3 (PMID: 26048680). 26048680
FGFR2 V564F FGFR2-BICC1 cholangiocarcinoma predicted - resistant BGJ398 Clinical Study Actionable In a clinical study, FGFR2 V564F was identified in the cell-free DNA of a cholangiocarcinoma patient harboring FGFR2-BICC1 fusion after the patient progressed while on BGJ398 treatment (PMID: 28034880). 28034880
FGFR2 V564F Advanced Solid Tumor resistant AZD4547 Preclinical - Cell line xenograft Actionable In a preclinical study, transformed cells over expressing FGFR2 V564F were resistant to AZD4547 in culture and in cell line xenograft models (PMID: 25169980). 25169980
FGFR2 V564F Advanced Solid Tumor sensitive Debio 1347 Preclinical - Cell line xenograft Actionable In a preclinical study, Debio 1347 inhibited proliferation of transformed cells over expressing FGFR2 V564F in culture and inhibited tumor growth in cell line xenograft models (PMID: 25169980). 25169980
FGFR2 V564F Advanced Solid Tumor resistant BGJ398 Preclinical - Cell culture Actionable In a preclinical study, transformed cells over expressing FGFR2 V564F were resistant to BGJ398 in culture (PMID: 28034880). 28034880
FGFR2-CCDC6 liver cancer sensitive PRN1371 Preclinical - Pdx Actionable In a preclinical study, PRN1371 treatment resulted in tumor regression in patient-derived xenograft models of liver cancer harboring FGFR2-CCDC6 fusion (PMID: 28978721). 28978721
FGFR2-BICC1 Advanced Solid Tumor sensitive PD173074 Preclinical Actionable In a preclinical study, treatment with PD173074 prevented transformation of cells expressing FGFR2-BICC1 in culture (PMID: 24122810). 24122810
FGFR2-BICC1 Advanced Solid Tumor sensitive BGJ398 Preclinical Actionable In a preclinical study, treatment with BGJ398 prevented transformation of cells expressing FGFR2-BICC1 in culture (PMID: 24122810). 24122810