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Gene | BRAF |
Variant | P731S |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | BRAF P731S does not lie within any known functional domains of the Braf protein (UniProt.org). P731S results in increased transformation ability compared to wild-type Braf in one of two different cell lines in culture (PMID: 29533785), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Sep 2024). |
Associated Drug Resistance | |
Category Variants Paths |
BRAF mutant BRAF P731S |
Transcript | NM_004333.6 |
gDNA | chr7:g.140734707G>A |
cDNA | c.2191C>T |
Protein | p.P731S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_001354609.1 | chr7:g.140734707G>A | c.2191C>T | p.P731S | RefSeq | GRCh38/hg38 |
NM_004333.6 | chr7:g.140734707G>A | c.2191C>T | p.P731S | RefSeq | GRCh38/hg38 |
XM_005250045 | chr7:g.140734707G>A | c.2191C>T | p.P731S | RefSeq | GRCh38/hg38 |
NM_004333 | chr7:g.140734707G>A | c.2191C>T | p.P731S | RefSeq | GRCh38/hg38 |
NM_001354609.2 | chr7:g.140734707G>A | c.2191C>T | p.P731S | RefSeq | GRCh38/hg38 |
NM_004333.5 | chr7:g.140734707G>A | c.2191C>T | p.P731S | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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