Gene Variant Detail

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Gene BRAF
Variant P367R
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions BRAF P367R does not lie within any known functional domains within the Braf protein (UniProt.org). P367R confers a gain of function to the Braf protein as indicated by increased Erk phosphorylation in culture and tumor formation in animal models, and demonstrates resistance to Egfr inhibitors in culture (PMID: 27478040).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF P367X BRAF P367R

BRAF mutant BRAF act mut BRAF P367R

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Transcript NM_004333.5
gDNA chr7:g.140794348G>C
cDNA c.1100C>G
Protein p.P367R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017012559.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_017012558.1 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_005250045 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_017012558 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_004333 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
XM_017012559 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140794348G>C c.1100C>G p.P367R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References