Gene Variant Detail

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Gene BRAF
Variant S465D
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions BRAF S465D lies within the protein kinase domain of the Braf protein (UniProt.org). S465D results in basal Mek phosphorylation and Mek phosphorylation upon Ras activation to similar levels of wild-type Braf in culture (PMID: 27034005), and therefore, is predicted to have no effect on Braf protein function.
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF S465D

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Transcript NM_004333.5
gDNA chr7:g.140781614_140781615delTCinsGA
cDNA c.1393_1394delTCinsGA
Protein p.S465D
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140781614_140781615delGAinsTC c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140781614_140781615delTCinsGA c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
NM_004333 chr7:g.140781614_140781615delGAinsTC c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140781614_140781615delTCinsGA c.1393_1394delTCinsGA p.S465D RefSeq GRCh38/hg38

Filtering

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  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References