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|Protein Effect||no effect|
|Gene Variant Descriptions||APC dec exp indicates decreased expression of the Apc protein and/or mRNA. However, the mechanism causing the decreased expression is unspecified.|
|Associated Drug Resistance|
|Category Variants Paths|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|APC dec exp||colorectal cancer||predicted - sensitive||G007-LK||Preclinical||Actionable||In a preclinical study, G007-LK treatment altered gene expression pattern and induced growth arrest in intestinal organoids established from mouse models of colorectal cancer driven by APC knockdown, decreased proliferation and promoted differentiation in APC knockdown mouse models (PMID: 31337618).||31337618|