Gene Variant Detail

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Gene NRAS
Variant Q61R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS Q61R is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61R results in increased GTP-bound Nras, which leads to activation of Mapk signaling and cell transformation in culture (PMID: 16818621, PMID: 34117033), and is predicted to lead to a loss of GTPase activity based on the effect of HRAS Q61R (PMID: 3510078).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS Q61R

NRAS mutant NRAS exon3 NRAS Q61X NRAS Q61R

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Transcript NM_002524.5
gDNA chr1:g.114713908T>C
cDNA c.182A>G
Protein p.Q61R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114713908T>C c.182A>G p.Q61R RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713908T>C c.182A>G p.Q61R RefSeq GRCh38/hg38
NM_002524 chr1:g.114713908T>C c.182A>G p.Q61R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
NRAS Q61R loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600X MAP2K1 V60E NRAS T58I NRAS Q61R
KIT D816V NRAS Q61R
ATM mut NRAS Q61R
BRAF V600E MAP2K1 Q56P NRAS Q61R
BRAF N581S NRAS Q61R
FLT3 exon 14 ins FLT3 D835X NRAS Q61R
BRAF V600E NRAS Q61R