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Gene | PIK3CA |
Variant | G12D |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | PIK3CA G12D does not lie within any known functional domains of the Pik3ca protein (UniProt.org). G12D has been identified in sequencing studies (PMID: 23933559, PMID: 32947236), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, May 2024). |
Associated Drug Resistance | |
Category Variants Paths |
PIK3CA mutant PIK3CA G12D |
Transcript | NM_006218.4 |
gDNA | chr3:g.179198860G>A |
cDNA | c.35G>A |
Protein | p.G12D |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_006218.3 | chr3:g.179198860G>A | c.35G>A | p.G12D | RefSeq | GRCh38/hg38 |
XM_006713658.4 | chr3:g.179198860G>A | c.35G>A | p.G12D | RefSeq | GRCh38/hg38 |
XM_006713658 | chr3:g.179198860G>A | c.35G>A | p.G12D | RefSeq | GRCh38/hg38 |
NM_006218.4 | chr3:g.179198860G>A | c.35G>A | p.G12D | RefSeq | GRCh38/hg38 |
NM_006218 | chr3:g.179198860G>A | c.35G>A | p.G12D | RefSeq | GRCh38/hg38 |
XM_006713658.5 | chr3:g.179198860G>A | c.35G>A | p.G12D | RefSeq | GRCh38/hg38 |
XM_011512894 | chr3:g.179198860G>A | c.35G>A | p.G12D | RefSeq | GRCh38/hg38 |
XM_011512894.2 | chr3:g.179198860G>A | c.35G>A | p.G12D | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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