Gene Detail

Gene Symbol PIK3CA
Synonyms CLAPO | CLOVE | CWS5 | MCAP | MCM | MCMTC | p110-alpha | PI3K | PI3K-alpha
Gene Description PIK3CA, phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, activates AKT/mTOR signaling to promote cell proliferation (PMID: 23411347). PIK3CA activating mutations have been identified in a number of tumor types such as breast cancer, colon cancer, endometrial cancer, glioblastoma, skin cancer, and ovarian cancer (PMID: 20535651).
Entrez Id 5290
Chromosome 3
Map Location 3q26.32
Canonical Transcript NM_006218


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