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Gene PIK3CA
Variant A1066V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA A1066V does not lie within any known functional domains of the Pik3ca protein (UniProt.org). A1066V results in Akt phosphorylation levels similar to wild-type Pik3ca, but results in increased anchorage-independent colony formation and cell motility in conditions without growth factor in cell culture (PMID: 22430209), and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon21 PIK3CA A1066V

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Transcript NM_006218.4
gDNA chr3:g.179234354C>T
cDNA c.3197C>T
Protein p.A1066V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.4 chr3:g.179234354C>T c.3197C>T p.A1066V RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179234354C>T c.3197C>T p.A1066V RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179234354C>T c.3197C>T p.A1066V RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179234354C>T c.3197C>T p.A1066V RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179234354C>T c.3197C>T p.A1066V RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PIK3CA A1066V urinary bladder cancer resistant MK2206 Preclinical - Cell culture Actionable In a preclinical study, a bladder cancer cell line harboring PIK3CA A1066V, along with KRAS and NRAS mutations, was resistant to MK2206 in culture (PMID: 25349966). 25349966