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Gene | PIK3CA |
Variant | R357G |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | PIK3CA R357G lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). R357G has been identified in sequencing studies (PMID: 23797736), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Dec 2023). |
Associated Drug Resistance | |
Category Variants Paths |
PIK3CA mutant PIK3CA R357G |
Transcript | NM_006218.4 |
gDNA | chr3:g.179204512C>G |
cDNA | c.1069C>G |
Protein | p.R357G |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_011512894.2 | chr3:g.179204512C>G | c.1069C>G | p.R357G | RefSeq | GRCh38/hg38 |
XM_006713658.5 | chr3:g.179204512C>G | c.1069C>G | p.R357G | RefSeq | GRCh38/hg38 |
NM_006218.3 | chr3:g.179204512C>G | c.1069C>G | p.R357G | RefSeq | GRCh38/hg38 |
XM_006713658.4 | chr3:g.179204512C>G | c.1069C>G | p.R357G | RefSeq | GRCh38/hg38 |
NM_006218.4 | chr3:g.179204512C>G | c.1069C>G | p.R357G | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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