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Gene | PIK3CA |
Variant | C905S |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | PIK3CA C905S lies within the PI3K/PI4K domain of the Pik3ca protein (UniProt.org). C905S results in increased levels of cell migration but similar levels of cell proliferation and phosphorylation of Akt to wild-type Pik3ca and is not transforming in culture (PMID: 34779417), and therefore, its effect on Pik3ca protein function is unknown. |
Associated Drug Resistance | |
Category Variants Paths |
PIK3CA mutant PIK3CA C905S |
Transcript | NM_006218.4 |
gDNA | chr3:g.179230050T>A |
cDNA | c.2713T>A |
Protein | p.C905S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_006218.4 | chr3:g.179230050T>A | c.2713T>A | p.C905S | RefSeq | GRCh38/hg38 |
XM_006713658.5 | chr3:g.179230050T>A | c.2713T>A | p.C905S | RefSeq | GRCh38/hg38 |
XM_006713658.4 | chr3:g.179230050T>A | c.2713T>A | p.C905S | RefSeq | GRCh38/hg38 |
NM_006218.3 | chr3:g.179230050T>A | c.2713T>A | p.C905S | RefSeq | GRCh38/hg38 |
XM_011512894.2 | chr3:g.179230050T>A | c.2713T>A | p.C905S | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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