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|Gene Variant Descriptions||BRAF D448Y does not lie within any known functional domains of the Braf protein (UniProt.org). D448Y results in decreased sensitivity of Braf homodimers to drug-mediated disruption, and activation of truncated Braf dimers comparable to the wild-type protein in an in vitro assay in combination with D449Y (PMID: 30559419), but has not been individually characterized and therefore, its effect on Braf protein function is unknown.|
|Associated Drug Resistance|
|Category Variants Paths||
BRAF mutant BRAF D448Y
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|