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|Gene Variant Descriptions||CDKN2A hypermethylation indicates an increased methylation of the CDKN2A gene. However, the mechanism causing the hypermethylation is unspecified.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|CDKN2A hypermethylation||colorectal cancer||not applicable||N/A||Clinical Study - Meta-analysis||Prognostic||In a meta-analysis, CDKN2A promoter hypermethylation was associated with poor overall survival (HR=1.65, 95% CI 1.29-2.11), lymphovascular invasion (OR=1.68, 95% CI 1.15-2.47), and lymph node metastasis (OR=1.68, 95% CI 1.09-2.59) in colorectal cancer patients, and correlated significantly with poor overall survival in patients from Europe (HR=1.49, 95% CI 1.28-1.74) and Asia (HR=3.30, 95% CI 1.68-6.46) (PMID: 23703248).||23703248|
|Molecular Profile||Protein Effect||Treatment Approaches|