Gene Variant Detail

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Gene BRAF
Variant N486_L495del
Impact List deletion
Protein Effect gain of function - predicted
Gene Variant Descriptions BRAF N486_L495del results in the deletion of ten amino acids within the alphaC-helix region in the protein kinase domain of the Braf protein (PMID: 26732095, UniProt.org). N486_L495de has not been characterized, however, is predicted to result in a gain of function due to other characterized BRAF deletions in the same region (PMID: 26732095).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF act mut BRAF N486_L495del

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Transcript NM_004333.5
gDNA chr7:g.140778023_140778052del30
cDNA c.1456_1485del30
Protein p.N486_L495del
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.1 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495del RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140778023_140778052del30 c.1456_1485del30 p.N486_L495del RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

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  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries