Gene Variant Detail

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Gene NRAS
Variant Q61K
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS Q61K is a hotspot mutation that lies within a GTP-binding region of the Nras protein (UniProt.org). Q61K results in activation of downstream pathway signaling, increased survival, and transformation of cultured cells (PMID: 22718121, PMID: 34117033, PMID: 33431353), and is predicted to lead to a loss of Nras protein function based on the effects of HRAS Q61K (PMID: 3510078).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS Q61K

NRAS mutant NRAS exon3 NRAS Q61X NRAS Q61K

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Transcript NM_002524.5
gDNA chr1:g.114713909G>T
cDNA c.181C>A
Protein p.Q61K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114713909G>T c.181C>A p.Q61K RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713909G>T c.181C>A p.Q61K RefSeq GRCh38/hg38
NM_002524 chr1:g.114713909G>T c.181C>A p.Q61K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
NRAS Q61K loss of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)
BRAF V600E NRAS Q61K
CDKN2A loss NRAS Q61K
BRAF V600E MAP2K1 P387S NRAS Q61K
BRAF V600E MAP2K1 P387S NRAS Q61K NRAS A146T
BRAF V600K NRAS Q61K
BRAF V600E NRAS Q61K NRAS A146T
BRAF G469R NRAS Q61K
BRAF V600X BRAF amp NRAS Q61K
BRAF wild-type NRAS Q61K
BRAF L597V NRAS Q61K
BRAF G466V NRAS Q61K
BRAF G596R NRAS Q61K
BRAF G469V NRAS Q61K
ATM T1200Lfs*7 NRAS Q61K TP53 R213*
NRAS Q61K NRAS mut
BRAF D287H NRAS Q61K
BRAF loss NRAS Q61K
BRAF L597Q FGFR2 H167_N173del FGFR2 N550K FGFR2 L618F NRAS Q61K
BRAF V600E CDKN2A loss NRAS Q61K
FLT3 exon 14 ins NRAS Q61K
NRAS Q61K PIK3CA E545K
FLT3 exon 14 ins FLT3 D835X NRAS Q61K
ALK F1174L NRAS Q61K