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Gene | ALK |
Variant | F1245X |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ALK F1245X indicates any Alk missense mutation that results in replacement of the phenylalanine (F) at amino acid 1245 by a different amino acid. |
Associated Drug Resistance | |
Category Variants Paths |
ALK mutant ALK F1245X |
Transcript | NM_004304.5 |
gDNA | chr2:g.29213992_29213994 |
cDNA | c.3733_3735 |
Protein | p.F1245 |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004304.4 | chr2:g.29213992_29213994 | c.3733_3735 | p.F1245 | RefSeq | GRCh38/hg38 |
NM_004304.5 | chr2:g.29213992_29213994 | c.3733_3735 | p.F1245 | RefSeq | GRCh38/hg38 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
---|---|---|---|---|---|---|
NCT05004116 | Phase Ib/II | Irinotecan + Repotrectinib + Temozolomide | A Study of Repotrectinib in Combination With Chemotherapy in Children and Young Adults With Solid Tumor Cancer | Recruiting | USA | 0 |